Overview
Fructose-1,6-diphosphate (FDP) is a vital metabolic intermediate that occupies a central position in both glycolysis and gluconeogenesis pathways. As the first phosphorylated product in glycolysis, it serves as a key regulator of cellular energy production. Discovered in the early 20th century during yeast fermentation studies, FDP has gained pharmaceutical importance for its cytoprotective effects. The sodium salt form is commonly used in clinical applications, particularly for ischemia-reperfusion injury management.
Physical and Chemical Properties
FDP exists as a white, odorless crystalline powder that readily dissolves in water but shows limited solubility in organic solvents. The compound is relatively stable when dry but hydrolyzes in aqueous solutions, particularly under acidic or alkaline conditions. Its chemical structure contains two phosphate groups at the 1 and 6 positions of the fructose molecule, making it highly polar. This phosphorylation is crucial for its biological activity, enabling interaction with various enzymes in metabolic pathways.
Main Applications
In clinical medicine, FDP is administered intravenously as a cardioprotective agent during cardiac surgery, myocardial infarction, and shock. It works by improving cellular energy metabolism and reducing ischemic damage through multiple mechanisms. Beyond medical use, FDP serves as an important reagent in biochemical research, particularly in studies of glycolysis regulation. It's also used in specialized cell culture media and as a reference standard in analytical chemistry for metabolic pathway analysis.
Safety and Storage
FDP requires careful handling to maintain stability and prevent degradation. The powder should be stored in sealed containers under refrigeration (2-8°C) with desiccants to prevent moisture absorption. While generally considered low in acute toxicity, FDP powder can cause irritation to mucous membranes and eyes. Appropriate personal protective equipment including gloves and safety glasses should be worn when handling. Solutions should be prepared under aseptic conditions for medical applications.
B2B Procurement Guide
When sourcing FDP for pharmaceutical applications, buyers should prioritize suppliers with GMP certification and documented quality control procedures. Key specifications include purity (typically ≥98%), low endotoxin levels (<0.05 EU/mg), and absence of heavy metal contaminants. For research-grade material, consider the supplier's analytical documentation including HPLC chromatograms and NMR spectra. Bulk procurement (10kg+) may offer cost advantages, but ensure proper storage capacity is available. Special transport conditions may be required for international shipments to maintain product stability.
Related Manufacturers
- 主营：化学品、香精香料、试剂、中间体、有机硅、橡胶树脂、催化剂、纳米材料
- 主营：架桥剂、YW100 锂萃取剂、端羧基液体丁腈橡胶、苯乙烯磷酸、乙烯基磷酸二乙酯、磷酸锰铁锂、β-磷酸三钙、间二异丙苯、10-羟基癸酸、肉豆蔻酸镁、硬脂酸钴、全氟三丁胺、十一烯酸、钨酸铝、1-乙炔基环已醇、锂硅合金、溴甲酚绿、生物活性玻璃、溴代海因树脂颗粒、红铝、龙涎酮、原丁酸三甲酯
- 主营：甘氨酸、水苏糖、阻燃剂、磷酸铁、磷酸铝、硫酸锌、硫酸锆、硫酸锂、硫酸锶、硫酸锰、铝酸锌、1680-21-3、牛磺酸、褪黑素、丙酸铵、苏云金、碳酸镁、麝香酮、肉桂醛、王浆酸、椰油胺、赖氨酸、增塑剂、浸膏粉、乙氧基
- 主营：甘氨酸、儿茶黑、水苏糖、二磷酸果糖三钠盐、红曲黄、可可壳、脆皮素、维纶胶、五香粉、硫酸锰、相苷酶、肌氨酸、除腥剂、烟酰胺、牛磺酸、褪黑素、碳酸镁、温轮胶、脯氨酸、叶绿素、冰乙酸、酸性红、淀粉钠、脂肪酶、大蒜粉、右旋糖
- 主营：保健食品代加工、固体饮料、口服液、二磷酸果糖、运动员特膳产品、软胶囊、10ml口服液代加工、孕妇乳母特膳、压片糖果、胶囊代加工、凝胶糖果、植物饮品、醋蛋液、保健食品、辅酶Q10、胶原蛋白肽、螯合钙、PQQ胶原蛋白肽饮、特殊膳食、驼奶粉代加工、药食同源口服液、口服液oem代加工、植物饮品代加工、麦角硫因代加工、麦角硫因
- 主营：叔碳酸、十八醛、溶菌酶、癸二醇、邻苯二甲、乙基碳二、烷二甲醇、vc磷酸酯镁、癸烷撑二醇、海藻糖、氨基丙基、氢路噻嗪、羟基癸酸、正十七烷、谷胱甘肽、松果体素、2-甲基丁醛、朱栾倍半萜、丁烷四乙酸、表面活性剂、缩水甘油邻、10-羟基羊蜡酸、氢氯噻嗪杂质、盐酸邻菲罗啉、壳聚糖季铵盐
- 主营：聚苯胺、脯氨酸甲酯盐酸盐、苄基三甲基氯化铵
- 主营：5-三甲基己醛、正癸酸、樊多B醛、聚乙二醇甲醚甲基丙烯酸酯、二氧化钒、3二羟基萘、二苯酮、山梨醇缩水甘油醚、聚苯胺、磷脂酸铵盐、谷胱甘肽、三羟甲基氨基甲烷盐酸盐、庚酰氯、菲尼酮、茶香醇、苹果酸、菠萝醚
- 主营：果糖二磷酸钠、麦芽糖酸、苯氧基环磷腈、甲巯基四氮唑
- 主营：葛根提取物、姜黄素、羊奶粉、甘草酸二钾、苯乙基间苯二酚、鱼油、蝶豆花粉、魔芋精粉、牦牛骨肽、蓝莓粉、胶原三肽、破壁松花粉、藤黄果提取物、椰子油粉、β-胡萝卜素、亚麻籽油微囊粉、叶黄素、槲皮素、葛根黄酮、光甘草定、蓝莓花青素、中链甘油三酯、共轭亚油酸粉、玉米肽、沙棘冻干粉
- 主营：二磷酸果糖、elisa 试剂盒
- 主营：十八硫醇、碳酸铯、猪胆酸钠、单磷酸钠、二甲基吡啶、脱氧胆酸钠、石胆酸、钛酸酯偶联剂、乙烯硫脲、玫瑰草油、乙酰化透明质酸钠、吗啉丙磺酸、亚甲基双丙烯酰胺、氧化锌、聚醋酸乙烯酯、对碘苯甲酸甲酯
- 主营：四丁基溴化铵、半胱胺盐酸盐、莫能菌素、异山梨醇二甲醚、二氢茉莉酮酸甲酯、二氢吡啶原粉、二氢燕麦生物碱、二硫代二甘醇酸二铵、己脒定二(羟乙基磺酸、对氯间二甲苯酚、月桂酰赖氨酸、双马来酰亚胺BMI、福美钠、辛酰氧肟酸、巯基乙酸乙醇胺、乙醛酸固体、四丙基氢氧化铵、巯基乙酸铵、蓖麻油酸锌、蓖麻油酸锌脂、三乙酰氧基硼氢化钠、辛酰羟肟酸
- 主营：二磷酸果糖、检测试剂盒、elisa试剂盒
- 主营：化工原料、香精香料、饲料添加剂、聚乙二醇PEG、二醋酸纤维素、食品添加剂、农药原药、中间体、十一烯酸锌、五氯硫酚、吲哚、敌草隆、对叔戊基苯酚、溴氰菊酯、愈创木酚、邻碘苯甲酸、甲基三氧化铼、N-羟乙基丙烯酰胺、聚六亚甲基单胍盐酸盐、右旋樟脑磺酸、对羟基苯磺酸钠、N-氨甲酰谷氨酸、胺鲜酯、壳聚糖季铵盐、戊唑醇