Overview
Fraxin is a naturally occurring coumarin glycoside extracted from the bark of Fraxinus species (ash trees), traditionally used in Chinese herbal medicine. As a reference standard, it serves as a critical tool for quality control in pharmaceutical and botanical product analysis. The compound is characterized by its distinct UV absorption and fluorescence properties, making it suitable for HPLC and LC-MS applications. In B2B transactions, fraxin reference standards are typically supplied with comprehensive certificates of analysis (CoA) detailing purity, spectroscopic data, and chromatographic profiles. Pharmaceutical manufacturers and research laboratories rely on these standards to validate analytical methods and ensure product consistency.
Physical and Chemical Properties
Fraxin exhibits typical coumarin characteristics with a molecular weight of 370.31 g/mol. Its crystalline form is stable under recommended storage conditions but may degrade upon prolonged exposure to light or moisture. The glycosidic linkage contributes to its moderate solubility in polar organic solvents like methanol (50 mg/mL), while aqueous solubility is limited (1-5 mg/mL at 25°C). Spectroscopic properties include strong UV absorption at 254 nm and 340 nm, with fluorescence emission at 450 nm (excitation at 340 nm). These features enable sensitive detection in chromatographic systems. The compound shows stability in pH ranges of 4-8 but may hydrolyze under strongly acidic or alkaline conditions.
Main Applications
Fraxin reference standards are primarily used in pharmaceutical quality control for traditional Chinese medicine preparations containing Fraxinus bark extracts. They enable quantification of active components and detection of adulterants in herbal products. Research laboratories employ fraxin to study its purported anti-inflammatory and antioxidant bioactivities. In analytical chemistry, the compound serves as a marker for method validation in HPLC-UV and LC-MS/MS systems. Regulatory agencies may require fraxin standardization for herbal drug registration dossiers. Some cosmetic manufacturers also utilize it as a natural bioactive ingredient in skincare formulations.
Safety and Storage
Fraxin reference materials are generally classified as low-risk substances but should be handled with standard laboratory precautions. Direct contact may cause mild irritation; nitrile gloves and safety goggles are recommended. No significant vapor pressure has been observed at room temperature, minimizing inhalation risks. For long-term stability, store unopened vials at 2-8°C with desiccant. Working solutions in methanol remain stable for 2 weeks when refrigerated. Discard discolored samples. Material Safety Data Sheets (MSDS) should be consulted for specific disposal procedures in accordance with local regulations.
B2B Procurement Guide
When sourcing fraxin reference standards, prioritize suppliers with ISO 17025 accreditation for reference material production. Key procurement considerations include batch-specific purity documentation (preferably ≥98%), residual solvent analysis, and chromatographic purity verified by multiple detection methods (UV, ELSD, CAD). For regulatory applications, ensure the certificate includes full method validation data (LOD, LOQ, linearity range). Request stability studies under proposed storage conditions. Bulk purchases (100mg+) may qualify for tiered pricing, but verify shelf life. Some suppliers offer customized solutions (e.g., pre-weighed ampoules) to minimize handling errors in QC labs.
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