Overview
Formylthiazole is an organic compound derived from thiazole, characterized by a formyl functional group attached to the heterocyclic ring. It serves as a versatile intermediate in the synthesis of pharmaceuticals and agrochemicals due to its reactive aldehyde group and aromatic structure. The compound is typically supplied as a colorless to pale yellow liquid and must be handled with care due to its irritant properties. Its significance in organic synthesis stems from the ability to undergo further chemical transformations, such as condensation or reduction reactions, making it valuable for constructing complex molecules. Industrial demand is driven by its role in producing active pharmaceutical ingredients (APIs) and crop protection agents.
Physical and Chemical Properties
Formylthiazole has a molecular weight of 113.14 g/mol and is soluble in common organic solvents like ethanol, acetone, and dichloromethane. The formyl group (-CHO) at the 4-position of the thiazole ring enhances its reactivity, enabling participation in nucleophilic addition reactions. While specific melting and boiling points are not widely documented, the compound is stable under recommended storage conditions but may degrade upon prolonged exposure to air or moisture. The aromatic thiazole core contributes to its stability and influences electronic properties, which are exploited in coordination chemistry and material science applications. Analytical methods such as NMR and IR spectroscopy are typically used to confirm its structure and purity.
Main Applications
In the pharmaceutical industry, formylthiazole is a key building block for synthesizing thiazole-containing drugs, including antivirals and antibiotics. Its formyl group allows for facile derivatization, enabling the creation of Schiff bases or heterocyclic extensions. Agrochemically, it is utilized in the production of fungicides and herbicides, where the thiazole moiety enhances bioactivity. Beyond these sectors, the compound finds niche uses in material science, particularly in the development of conductive polymers or ligands for metal-organic frameworks (MOFs). Research applications often focus on its role in multicomponent reactions to generate libraries of bioactive compounds.
Safety and Storage
Formylthiazole is classified as an irritant, requiring handling with gloves, goggles, and adequate ventilation. Direct contact with skin or eyes may cause inflammation, and inhalation of vapors should be avoided. Spills must be contained with inert absorbents and disposed of as hazardous waste. Storage recommendations include keeping the compound in a tightly sealed container under inert gas (e.g., nitrogen) to prevent oxidation. Temperature-controlled environments (2–8°C) are advised for long-term stability. Compatibility with common lab materials like glass and stainless steel ensures safe transport and processing.
B2B Procurement Guide
When sourcing formylthiazole, prioritize suppliers with ISO certification and batch-specific certificates of analysis (CoA). Key parameters to verify include purity (≥98% by HPLC), water content, and residual solvents. Bulk buyers should negotiate contracts with flexible delivery terms, as demand fluctuates with R&D cycles in pharmaceuticals. For international procurement, consider incoterms (e.g., CIF or DDP) to manage logistics costs. Sample testing is recommended to confirm consistency, especially for GMP-grade material. Establish contingency plans with alternate suppliers to mitigate supply chain disruptions.
Related Manufacturers
- 主营：离子液体、阻燃剂、咪唑、香兰基丁醚、全氟辛基三甲氧基硅烷、叔丁基乙烯基醚、丙酮缩氨基硫脲、催化剂、乙酰丙酮钴、正丁醇锆、四氟硼酸锂、氟化物、丙酮肟、双酚E型氰酸酯、钯碳催化剂、钛硅分子筛、硫酸烟酰苯胺
- 主营：甘氨酸、水苏糖、阻燃剂、乙氧基、硫酸锌、硫酸锆、硫酸锂、硫酸锶、硫酸锰、铝酸锌、1680-21-3、牛磺酸、褪黑素、磷酸铁、丙酸铵、苏云金、碳酸镁、麝香酮、肉桂醛、磷酸铝、王浆酸、椰油胺、赖氨酸、增塑剂、浸膏粉
- 主营：乙基黄原酸钾、乙酸龙脑酯、聚苯乙烯磺酸钠、2-十一酮
- 主营：硼酸酐、阻聚剂、己二酸、甲酸钠、氯化锂、发泡剂、乙二醇、醋酸铜、硅酸钠、正癸醇、新癸酸、环烷油、腰果酚、十二醇、酒石酸、碳酸锂、三甘醇、油菜酸、二甘醇、碳酸钾、硅酸镁、棕榈油、6-氯嘌呤、微晶石蜡、磷酸一铵
- 主营：苯氧基环磷腈、甲巯基四氮唑、麦芽糖酸
- 主营：方石英、阻燃剂、萃取粉、甲酸镍、羟乙基、香果香、藏花醛、桦木油、稀释剂、淀粉钠、洗涤剂、润肤剂、乙酸锶、氧化剂、防腐剂、铬酸锌、丙氨酸、二胜肽、成核剂、羊毛醇、氢氟油、壳聚糖、厚朴酚、镍试剂、钛酸铅
- 主营：亚索化学试剂、化学试剂、生物试剂、基准试剂、检测试剂、化学色谱纯试剂、光谱纯试剂、分析纯AR试剂、优级纯GR试剂、高纯电子级试剂、标准化学试剂、滴定分析试剂、实验室试剂、通用试剂
- 主营：酰亚胺、苯磺酸、cas-50-63-5、苯甲醛、异丙基、氨基丙基、甲基硅基、苄基丙酮、甲基乙炔、二咪唑羰基、试剂医药、化学醋酸、化学试剂、盐酸羟胺、苯并三唑、试剂化工、丙烯酰氯、氮杂苯并、二叔丁酯、磷酸二苯酯、化学碳酸钾、二酸二乙酯、酸二异丙酯、中间体化工、医药中间体
- 主营：萃取剂、选矿药剂、金矿硫化矿
- 主营：十八硫醇、碳酸铯、猪胆酸钠、亚甲基双丙烯酰胺、二甲基吡啶、对碘苯甲酸甲酯、脱氧胆酸钠、石胆酸、钛酸酯偶联剂、乙烯硫脲、单磷酸钠、玫瑰草油、乙酰化透明质酸钠、吗啉丙磺酸、氧化锌、聚醋酸乙烯酯
- 主营：6485-39-8、2316-26-9、甘氨酸、甲基、3189-13-7、4368-51-8、阻燃剂、红曲黄、1079-66-9、2920-38-9、3087-36-3、9012-76-4、127-47-9a、硫酸锰、4861-19-2、1313-96-8、3687-46-5、7659-86-1、7681-52-9、3458-28-4、吐温t20、牛磺酸、灭火剂、肉桂醇、1189-71-5、布龙酸
- 主营：甲酰基噻唑、环酸、异构十醇
- 主营：4甲基5甲酰基噻唑、导电态聚苯胺
- 主营：蓬松剂、异辛醇、化妆品、双羟乙基、酰胺丙基三、三甲基氯化铵、甲基葡萄糖苷、n-甲基吡咯烷酮、异辛酸、护发素、二乙二醇、反应试剂、三乙醇胺、苯磺酸钠、粘合剂涂料、表面活性剂、阳离子纤维素
- 主营：甲氧基聚乙二醇丙烯酸酯、甲基丙烯酸叔丁氨基乙酯、乙酰肼、2'-联吡啶、丙半胱氨酸