Overview
Fluoroquinolones, referred to as 'Sha Xing' in Chinese, are a class of synthetic antibiotics derived from nalidixic acid. They are widely used in both human and veterinary medicine due to their broad-spectrum antibacterial activity. These compounds are particularly effective against Gram-negative bacteria but also show activity against some Gram-positive strains. The development of fluoroquinolones marked a significant advancement in antibiotic therapy, offering improved pharmacokinetic properties and fewer side effects compared to earlier quinolones. They work by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription.
Physical and Chemical Properties
Fluoroquinolones are typically white or off-white crystalline powders with varying solubility characteristics. They are generally stable under normal storage conditions but may degrade when exposed to strong light or extreme temperatures. The specific physical and chemical properties depend on the particular fluoroquinolone compound. Most fluoroquinolones exhibit good stability in solid form but may show reduced activity in solution, especially when exposed to alkaline conditions. Their melting points typically range between 200-300°C, and they are often slightly soluble in water but more soluble in organic solvents like methanol or dimethyl sulfoxide.
Main Applications
Fluoroquinolones are primarily used to treat various bacterial infections, including urinary tract infections, respiratory infections, skin infections, and gastrointestinal infections. They are particularly valuable for treating infections caused by Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa. In veterinary medicine, fluoroquinolones are used to treat bacterial infections in livestock and companion animals. Some formulations are also used in ophthalmic solutions for eye infections. The specific application depends on the particular fluoroquinolone compound and its spectrum of activity.
Safety and Storage
Fluoroquinolones should be handled with appropriate precautions in laboratory and pharmaceutical settings. Personnel should wear protective equipment to avoid inhalation or skin contact. These compounds should be stored in tightly sealed containers in cool, dry conditions, protected from light and moisture. From a clinical perspective, fluoroquinolones carry certain safety considerations. They are generally contraindicated in pregnant women and children due to potential effects on cartilage development. Some fluoroquinolones may cause photosensitivity, requiring patients to avoid excessive sunlight exposure during treatment.
B2B Procurement Guide
When procuring fluoroquinolones for pharmaceutical or research purposes, buyers should verify the supplier's certifications and compliance with Good Manufacturing Practice (GMP) standards. It's essential to confirm the compound's purity, typically requiring 98% or higher for pharmaceutical applications. Buyers should request detailed product specifications, including analytical certificates and stability data. Consider ordering small test quantities before large purchases to verify quality. Given regulatory variations, ensure the specific fluoroquinolone compound is approved for use in your target market. Pricing varies significantly based on quantity, purity, and specific compound, with bulk purchases typically offering better value.
Related Manufacturers
- 主营：松香树脂、回收颜料、回收化工原料、化工助剂溶剂
- 主营：聚乙二醇、聚丙二醇、叔胺、伯胺、染料中间体
- 主营：DMF、DMAC、二丙酮醇、左旋氧氟沙星羧酸、四甲基胍、马来酸酐、丙二醇、乙二醇、甲酸、甲醇、十二醇、柠檬酸、己二醇、甘油、四氢呋喃、碳酸丙烯酯、吐温、无水氯化钙、乙酸乙酯、氢氧化钠、二乙醇胺、司盘、过硫酸钠、氧化钙、氯化钾
- 主营：硼酸酐、阻聚剂、己二酸、左旋氧氟沙星羧酸、氯化锂、发泡剂、乙二醇、醋酸铜、硅酸钠、正癸醇、新癸酸、环烷油、腰果酚、十二醇、酒石酸、碳酸锂、三甘醇、油菜酸、二甘醇、碳酸钾、甲酸钠、硅酸镁、棕榈油、6-氯嘌呤、微晶石蜡、磷酸一铵
- 主营：黄曲霉检测卡、牛早孕检测卡、黄曲霉素检测试剂盒、氧氟沙星检测试剂盒、霉菌毒素检测仪、牛结核检测卡、农药残留检测试剂盒、水产检测试剂盒、兽药残留检测试剂盒、呕吐毒素elisa试剂盒、黄曲霉荧光定量检测试纸、瘦肉精检测卡
- 主营：恩诺沙星检测仪、水质检测仪
- 主营：有机原料、中间体、香精香料、催化剂、有机硅、表面活性剂
- 主营：叔碳酸、十八醛、溶菌酶、甲磺酸达氟沙星、海藻糖、癸二醇、氨基丙基、氢路噻嗪、邻苯二甲、乙基碳二、羟基癸酸、正十七烷、谷胱甘肽、烷二甲醇、松果体素、vc磷酸酯镁、2-甲基丁醛、朱栾倍半萜、丁烷四乙酸、表面活性剂、癸烷撑二醇、缩水甘油邻、10-羟基羊蜡酸、氢氯噻嗪杂质、盐酸邻菲罗啉、壳聚糖季铵盐
- 主营：比浊仪、检测仪、测定仪、恩诺沙星检测仪、测油仪、氧分析仪、光光度计、液萃取仪、指数分析仪、总氮分析仪、辐射剂量仪、凝胶成像仪、流速流量计、在线分析仪、回流消解仪、气体分析仪、水质分析仪、明渠流量计、在线监测仪、吸收光谱仪、发光成像系统、便携式露点仪、一体化蒸馏仪、水质观测系统、手持式浊度仪、在线监测系统
- 主营：6-二羟基吲哚、磷钼酸、艾拉莫德中间体、德拉沙星葡甲胺盐、甲基丙二酸、光引发剂、苯芴醇、溴芬酸钠中间体、樟脑醌、钼酸钾、丝素蛋白、盐酸胍、β-丙氨酸甲酯盐酸盐、聚二羟基吲哚、7-去氢胆固醇、甘氨胆酸钠盐、半叶素、胆固醇、2-辛基十二醇、蛋白酶K、D-荧光素钾盐、光引发剂LAP、BIS-TRIS、甲基丙烯酸氧杂环丁烷
- 主营：甘氨酸、滑石粉、三甘醇、硫醚沙星、生桐油、水杨酸、葡聚糖、石英砂、薄荷脑、苯甲醇、平平加、丁酸钠、磷酸氢、扩散剂、漂白精、硬脂酸、消泡剂、蛋白胨、硫化锌、磷酸铁、黄糊精、硫酸钾、磷酸铝、磷铁粉、雷米邦、氧化铅
- 主营：福美钠、五氧化二钒、氨基磺酸、硫醚沙星厂家、氨基化锂、焦性没食子酸、次氯酸钙、漂粉精、酪蛋白胨、甘油、九水硫化钠、牛油脂肪酸、酵母膏、氟硅酸钠、单乙醇胺、氢氧化钾、氟化钠、氟化钙、氧化铅、油酸钠、偏钒酸铵、氢氧化钡、EVA乳液、二硫化钼、氟化氢钾
- 主营：固体酸催化剂、重组胶原蛋白、硅油、甲磺酸达氟沙星、特种硅油、聚硅氮烷、硼酸铝晶须、碳化硅晶须、t-BAMBP萃取剂、全氟三丁胺
- 主营：偏钒酸钠、还原铁粉、次磷酸钠、左旋氧氟沙星羧酸、金属有机物、二水氯化铜、对二氯苄、次磷酸、黄血盐钾、黄血盐钠、氟化钾、氟化钠、红丹粉、黄丹粉、硫氰酸钠、硫氰酸钾、乙二胺四乙酸二钾
- 主营：氯化锌、玻璃粉、冰醋酸、硫醚沙星、茶皂素、甘氨酸、渗透剂、棕榈酸、氯化钾、靛蓝粉、磷酸钙、eva乳液、氟化钾、堵漏王、早强剂、三甘醇、亚油酸、木质素、氟化钠、铵明矾、pvc树脂、富马酸、白糊精、壳聚糖、苯丙乳液、三乙二醇