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Fluorocyclopropyl

Updated: 2026-07-22

Overview

Fluorocyclopropane, also known as cyclopropyl fluoride, is a fluorinated hydrocarbon with the molecular formula C3H5F. It is a colorless gas that is used primarily in organic synthesis and as an intermediate in pharmaceutical manufacturing. The compound is notable for its reactivity and is often employed in the creation of more complex fluorinated organic molecules. Due to its highly flammable nature, fluorocyclopropane requires careful handling and storage. It is typically stored in pressurized containers and should be kept away from heat and open flames. The compound's reactivity makes it valuable in synthetic chemistry, particularly in reactions where the introduction of a fluorine atom is desired.

Physical and Chemical Properties

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Fluorocyclopropane is a colorless gas with a molecular weight of 60.07 g/mol. It has a density of approximately 1.1 g/cm³ and a boiling point around -30°C. The compound is slightly soluble in water but dissolves readily in many organic solvents, making it useful in various chemical reactions. The key chemical property of fluorocyclopropane is its reactivity, particularly in reactions involving the cyclopropane ring or the fluorine atom. This reactivity is exploited in organic synthesis to create more complex molecules. The compound is also highly flammable, necessitating strict safety measures during handling and storage.

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Main Applications

Fluorocyclopropane is primarily used in organic synthesis, where it serves as a building block for more complex fluorinated compounds. Its reactivity makes it valuable in the pharmaceutical industry, where it is used to create intermediates for drug development. The compound's ability to introduce fluorine atoms into organic molecules is particularly useful in the synthesis of bioactive compounds. In addition to pharmaceuticals, fluorocyclopropane finds applications in the production of specialty chemicals and materials. Its unique properties make it a versatile reagent in synthetic chemistry, enabling the creation of compounds with specific fluorination patterns that are difficult to achieve with other reagents.

Safety and Storage

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Fluorocyclopropane is a highly flammable gas and must be handled with care. It should be stored in a cool, well-ventilated area away from ignition sources. Proper personal protective equipment (PPE), including gloves and eye protection, should be worn when handling the compound. In case of a leak or spill, the area should be evacuated immediately, and the gas should be allowed to dissipate in a well-ventilated space. Firefighting measures for fluorocyclopropane include the use of dry chemical powder or carbon dioxide extinguishers. Water should not be used, as it may spread the fire.

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B2B Procurement Guide

When procuring fluorocyclopropane, it is essential to work with reputable suppliers who comply with safety and quality standards. Buyers should verify the supplier's certifications and ensure that the compound is delivered in appropriate containers with proper labeling. Price ranges for fluorocyclopropane can vary significantly depending on the quantity and supplier. Bulk purchases may offer cost savings, but buyers should also consider storage and handling requirements. It is advisable to request material safety data sheets (MSDS) and conduct a risk assessment before procurement.

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