Overview
20-Hydroxyecdysone is a principal molting hormone in arthropods and a bioactive phytoecdysteroid found in plants like Cyanotis vaga and spinach. It regulates developmental transitions in insects by binding to ecdysone receptors. Industrially, it is extracted from plants or synthesized for use in agriculture, nutraceuticals, and research. Unlike synthetic pesticides, 20-hydroxyecdysone offers an eco-friendly alternative by disrupting insect molting without harming vertebrates. Its anabolic effects in mammals have also spurred interest in sports medicine and anti-aging formulations.
Physical and Chemical Properties
As a crystalline steroid, 20-hydroxyecdysone is thermally stable up to its decomposition point (~240°C). Its solubility profile favors polar organic solvents, with limited water solubility (0.3 mg/mL at 25°C), which influences formulation strategies for agricultural sprays. The molecule contains multiple hydroxyl groups, making it hygroscopic. UV-Vis spectroscopy shows maximum absorption at 242 nm, a characteristic used for purity analysis. Its stereochemistry is critical for bioactivity—synthetic analogs often show reduced efficacy.
Main Applications
In agriculture, 20-hydroxyecdysone is formulated as a biopesticide targeting Lepidoptera larvae, causing lethal molting defects. Field trials demonstrate 70-90% efficacy against cotton bollworms at 100-200 ppm concentrations. The nutraceutical industry utilizes it in muscle-building supplements (typically 50-200 mg/day doses) due to its protein synthesis enhancement. Research indicates it may aid glucose metabolism, prompting studies for diabetes management. Pharmaceutical applications include wound healing adjuvants and stress resistance modulators.
Safety and Storage
20-Hydroxyecdysone exhibits low acute toxicity (LD50 >5,000 mg/kg in rats). However, prolonged exposure may cause hormonal imbalances in non-target organisms. Proper storage requires desiccants and inert gas blankets to prevent oxidation. Regulatory status varies: the EU approves it as a food supplement ingredient, while the FDA classifies it as a dietary component. Workplace handling requires NIOSH-approved dust masks to prevent respiratory irritation from fine particles.
B2B Procurement Guide
Bulk buyers should prioritize suppliers providing COA with HPLC purity (≥95% for industrial use, ≥98% for pharma). MOQs typically start at 1 kg, with discounts at 10+ kg orders. Key procurement regions include China (for plant extracts) and Germany (for synthetic variants). For agricultural formulations, emulsifiable concentrates (EC) with 10-20% active content are cost-effective. Third-party testing for heavy metals (≤10 ppm) and microbial limits is essential for GMP compliance. Lead times average 2-4 weeks for custom concentrations.
Related Manufacturers
- 主营：试剂盒、ELISA试剂盒、科研ELISA试剂盒、PCR试剂盒、生化试剂盒
- 主营：鱼蜕皮激素、检测试剂盒、elisa试剂盒
- 主营：鱼蜕皮激素、Elisa试剂盒、检测试剂盒
- 主营：醉茄提取物、二氢杨梅素、一水肌酸、蜕皮激素、硫辛酸、姜黄素、叶黄素、曲酸、大黄素、白藜芦醇、传明酸、脂质体NMN、木犀草素、葛根素、积雪草甙、L-谷胱甘肽、水溶醉茄提取物
- 主营：油莎豆提取物、黄精多糖、山药粉、胡萝卜提取物、人参提取物、百合提取物、绿豆提取物、蚕蛹蛋白粉、蒲公英多糖、粉葛提取物、五指毛桃粉、覆盆子提取物、三七提取物、绣球菌速溶粉、枸杞提取物、甘草提取物、青苹果果粉、牛骨胶原蛋白肽、葛根提取物、银杏叶提取物、胖大海浸膏粉、海参多肽、绞股蓝浓缩粉、酸枣仁提取物、牛骨髓粉
- 主营：苦参碱、氧化苦参碱、七叶皂苷钠、鱼藤酮、七叶皂苷、黑米花色苷、鬼臼树脂、鬼臼毒素、黑米花青素、龙胆苦苷、青蒿琥酯、青蒿素、吴茱萸碱、吴茱萸次碱、博落回总碱、二苯乙烯苷、丝肽粉、人参皂甙
- 主营：黄芩素、大蒜素、南非醉茄提取物、蜕皮激素、喜来芝提取物、锯叶棕脂肪酸、芦荟甙、红车轴异黄酮、水溶白藜芦醇、弗斯可林、武靴藤酸、乳香酸、洋蓟酸、刺梨SOD、岩藻黄质、松果菊苷
- 主营：elisa 试剂盒、Elisa试剂盒、进口试剂盒、蜕皮激素elisa试剂盒、国产试剂盒、试剂、细胞、ELISA检测试剂盒、酶联免疫法、酶联免疫试剂盒、酶活性检测、酶标仪检测
- 主营：试剂盒、人25羟基维生素、人低氧诱导因子
- 主营：科研试剂盒、酶免试剂盒、elisa试剂盒、昆虫蜕皮激素、细胞、生物试剂、进口ELISA试剂盒、PCR试剂盒、生化测试盒
- 主营：甘氨酸、儿茶黑、水苏糖、露水草蜕皮激素、红曲黄、可可壳、脆皮素、维纶胶、五香粉、硫酸锰、相苷酶、肌氨酸、除腥剂、烟酰胺、牛磺酸、褪黑素、碳酸镁、温轮胶、脯氨酸、叶绿素、冰乙酸、酸性红、淀粉钠、脂肪酶、大蒜粉、右旋糖
- 主营：甘草提取物、葛根提取物、沙棘提取物、枳椇子提取物、罗汉果提取物、酸枣仁提取物、茯苓提取物、枸杞提取物、山楂提取物、大枣提取物、山药提取物、黄精提取物、党参提取物、鸡内金提取物、马齿苋提取物
- 主营：酶cγ链、α2巨球、素d合成、植物蜕皮激素elisaKit、纤连蛋白、抗组蛋白、肌醇抗体、蛋白样环、敏感蛋白、牛骨钙素、蛋白重链、金属肽酶、乳球蛋白、钩端螺旋、蛋白激酶、高血糖素、钙调蛋白、小鼠α1抗、ELISA试剂盒、pcr检测试剂、生化检测试剂
- 主营：试剂盒、ELISA试剂盒、ELISA检测试剂盒
- 主营：有机原料、中间体、香精香料、蜕皮激素、催化剂、有机硅、表面活性剂