Overview
γ-Fagarine Standard is a purified alkaloid derived from plants of the Rutaceae family, particularly Zanthoxylum species. As a reference material, it plays a vital role in quality assurance for herbal medicine and pharmaceutical research. The compound is characterized by its quinoline-like structure and is widely recognized for its use as an analytical standard in chromatographic methods. In B2B contexts, γ-Fagarine Standard is typically supplied by specialized chemical manufacturers and distributors catering to laboratories and research institutions. Its primary value lies in its consistent purity and well-documented physicochemical properties, which enable accurate quantification and identification in complex matrices.
Physical and Chemical Properties
γ-Fagarine is a crystalline solid with a molecular weight of 229.23 g/mol and a melting point range of 180-182°C. Its molecular structure includes a methoxy-substituted quinoline core, contributing to its UV absorbance properties at ~254 nm and ~365 nm, making it suitable for HPLC-UV detection. The compound exhibits moderate solubility in polar organic solvents like methanol and ethanol but has limited solubility in water. Its stability is maintained under cool, dry conditions, though prolonged exposure to light or humidity may degrade the material. These properties are critical for its performance as an analytical standard.
Main Applications
The primary use of γ-Fagarine Standard is in pharmaceutical and botanical research, where it serves as a quantitative and qualitative reference for chromatographic analyses. It is essential for method development and validation in HPLC and LC-MS assays of Zanthoxylum extracts and related herbal products. Additionally, this standard supports pharmacological studies investigating γ-fagarine's bioactivities, including its potential antimicrobial and anti-inflammatory effects. In quality control laboratories, it helps ensure batch-to-batch consistency of herbal preparations containing this alkaloid.
Safety and Storage
As a laboratory chemical, γ-Fagarine Standard requires careful handling. Personal protective equipment (PPE) such as gloves and safety glasses should be worn to prevent skin contact or inhalation of dust. Although not classified as highly toxic, its biological activity warrants caution. Proper storage involves airtight containers under refrigeration (2-8°C) with desiccants to minimize moisture absorption. Prolonged exposure to room temperature or light may compromise purity. Suppliers typically provide stability data and recommended shelf life—usually 1-2 years when stored correctly.
B2B Procurement Guide
When procuring γ-Fagarine Standard, prioritize suppliers who provide comprehensive documentation, including a Certificate of Analysis (COA) with HPLC purity data (typically ≥98%), batch-specific chromatograms, and spectroscopic validation (e.g., MS, NMR). Reputable manufacturers often comply with ISO 17025 or similar standards. Bulk buyers should confirm scalability of supply and inquire about customization options (e.g., specific concentrations or solvent preparations). Pricing varies significantly with purity and quantity; negotiate volume discounts for orders above 100mg. Lead times may extend to 4-6 weeks for high-purity batches.
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