Overview
Eupalinolide C Standard is a sesquiterpene lactone compound isolated from Eupatorium lindleyanum (Lindley's thoroughwort), a medicinal plant used in traditional Chinese medicine. As a certified reference material, it serves as a critical quality control tool for laboratories studying the bioactive components of herbal medicines. The standard enables accurate quantification of eupalinolide C content in plant extracts and formulated products. Its development supports the standardization of herbal preparations, particularly in pharmacological research exploring its reported anti-inflammatory and anticancer activities.
Physical and Chemical Properties
This standard exhibits characteristic sesquiterpene lactone properties with a molecular weight of 344.4 g/mol. The crystalline powder shows optimal stability when stored frozen with desiccants, maintaining integrity for at least 24 months under recommended conditions. Chromatographic analysis typically shows a single peak in reverse-phase HPLC systems (e.g., retention time ~12.5 minutes on C18 columns with acetonitrile/water mobile phases). The compound demonstrates strong UV absorption around 220-240 nm, facilitating detection in analytical applications.
Main Applications
Primary use involves method development and validation for quality control in herbal drug manufacturing. Research laboratories employ it to establish calibration curves for HPLC and LC-MS quantification of eupalinolide C in complex botanical matrices. In drug discovery, the standard supports bioactivity studies investigating its potential as an NF-κB inhibitor. Pharmaceutical companies may use it as a marker compound for standardization of Eupatorium-derived preparations in compliance with pharmacopoeial requirements.
Safety and Storage
As a bioactive compound, proper handling requires PPE including nitrile gloves and safety goggles. Although not classified as acutely toxic, prolonged exposure may cause sensitization. Spills should be contained with inert absorbents and disposed as chemical waste. Long-term storage demands protection from oxidation and hydrolysis. Aliquotting into amber glass vials with nitrogen headspace is recommended for frequent-use samples. Shipping typically occurs with cold packs and desiccant packs to maintain stability during transit.
B2B Procurement Guide
When sourcing eupalinolide C standard, prioritize suppliers providing comprehensive analytical documentation including COA with batch-specific purity data, HPLC chromatograms, and spectral verification (NMR/MS). Minimum purity should exceed 95% for most research applications. For GMP applications, ensure the supplier can provide 21 CFR Part 11 compliant documentation. Bulk purchases (100mg+) may qualify for tiered pricing, but verify stability data supports intended storage duration. Consider suppliers offering parallel in-house isolation services for custom purity requirements.
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