Overview
Ethyl Chenodeoxycholate is a synthetic derivative of chenodeoxycholic acid, a primary bile acid. It is widely used in biochemical and pharmaceutical research due to its role in studying bile acid metabolism and cholesterol homeostasis. This compound is particularly valuable in drug development, where it serves as an intermediate or reference standard. Its ethyl ester form enhances solubility in organic solvents, making it suitable for experimental applications.
Physical and Chemical Properties
Ethyl Chenodeoxycholate appears as a white to off-white crystalline powder with a molecular weight of 420.63 g/mol. It is soluble in polar organic solvents like ethanol and DMSO but has limited solubility in water. The compound has a melting point range of 165-170°C, typical for bile acid derivatives. Its stability under standard laboratory conditions makes it suitable for long-term storage when kept dry and protected from light.
Main Applications
In pharmaceutical research, Ethyl Chenodeoxycholate is used to study bile acid transporters, liver function, and cholesterol-related disorders. It serves as a precursor in synthesizing other bile acid derivatives. The compound is also employed in biochemical assays to investigate metabolic pathways. Its applications extend to in vitro studies, where it mimics natural bile acids in experimental settings.
Safety and Storage
Ethyl Chenodeoxycholate should be handled with standard laboratory precautions, including gloves and eye protection. Inhalation or ingestion should be avoided, and proper ventilation is recommended. For storage, maintain the compound in a cool (2-8°C), dry environment, protected from light and moisture. Properly sealed containers prevent degradation and ensure long-term stability.
B2B Procurement Guide
When sourcing Ethyl Chenodeoxycholate, prioritize suppliers with verified purity certifications (e.g., ≥98% by HPLC). Confirm regulatory compliance (e.g., USP, EP) for pharmaceutical-grade material. Bulk procurement may offer cost advantages, but validate batch consistency and supplier reliability. Request COA (Certificate of Analysis) and ensure proper packaging to prevent contamination or degradation during transit.
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