Ethyl 3-(trifluoromethyl)crotonate

Updated: 2026-08-07

Overview

Ethyl 3-(Trifluoromethyl)crotonate is a chemical compound primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its molecular structure includes a trifluoromethyl group, which enhances its reactivity and utility in various chemical reactions. The compound is typically available as a colorless to pale yellow liquid. It is soluble in common organic solvents, making it versatile for laboratory and industrial applications. Due to its specialized nature, it is often sourced by B2B buyers in the chemical and pharmaceutical industries.

Physical and Chemical Properties

Ethyl 3-(Trifluoromethyl)crotonate is characterized by its molecular formula C7H9F3O2 and a molecular weight of 182.14 g/mol. The trifluoromethyl group in its structure contributes to its unique chemical properties, including increased reactivity and stability under certain conditions. The compound is volatile and should be handled with care to prevent exposure. Its solubility in organic solvents like ethanol and acetone makes it suitable for various synthetic processes. However, precise data on its density, melting point, and boiling point are not widely documented.

Main Applications

This compound is predominantly used as an intermediate in the pharmaceutical industry, where it plays a role in the synthesis of active pharmaceutical ingredients (APIs). Its reactivity makes it valuable for constructing complex molecular structures. In agrochemicals, Ethyl 3-(Trifluoromethyl)crotonate is utilized to develop pesticides and herbicides. The trifluoromethyl group enhances the efficacy of these products, making them more effective at lower concentrations. Its applications are niche but critical in these industries.

Safety and Storage

Ethyl 3-(Trifluoromethyl)crotonate requires careful handling due to its volatile and reactive nature. Personal protective equipment (PPE), including gloves and goggles, should be worn when working with this compound. Avoid inhalation and skin contact to prevent irritation or other adverse effects. Storage should be in a cool, dry place away from direct sunlight and moisture. Properly sealed containers are essential to maintain the compound's integrity and prevent contamination or degradation over time.

B2B Procurement Guide

When procuring Ethyl 3-(Trifluoromethyl)crotonate, it is crucial to verify the purity and reliability of the supplier. High-purity grades are often required for pharmaceutical applications, so certificates of analysis (CoA) should be requested. The reference price range is approximately $50-$200 per kilogram, depending on purity and supplier. Bulk purchases may offer cost savings, but buyers should ensure that storage and handling protocols are followed to maintain product quality.