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Ethoxypropionitrile

Updated: 2026-07-22

Overview

Ethoxypropionitrile, also known as 3-Ethoxypropionitrile, is an organic compound with the molecular formula C5H9NO. It is a colorless to pale yellow liquid with a characteristic odor. The compound is primarily used as an intermediate in organic synthesis and as a solvent in various industrial applications. Ethoxypropionitrile is valued for its reactivity and solubility in both water and organic solvents. Its versatility makes it a useful component in the production of pharmaceuticals, agrochemicals, and specialty chemicals. The compound is typically synthesized through the reaction of acrylonitrile with ethanol in the presence of a catalyst.

Physical and Chemical Properties

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Ethoxypropionitrile exhibits a density of approximately 0.92 g/cm³ and a boiling point range of 175-180°C. It is soluble in water and most organic solvents, making it a flexible choice for various chemical processes. The compound's molecular weight is 99.13 g/mol, and it is known for its high reactivity, particularly in nucleophilic substitution reactions. Due to its chemical structure, Ethoxypropionitrile can participate in a variety of reactions, including hydrolysis and reduction. Its stability under normal conditions makes it suitable for storage and handling in industrial settings, though precautions must be taken to avoid exposure to heat and open flames.

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Main Applications

Ethoxypropionitrile is widely used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its ability to act as a solvent and reactant makes it valuable in the production of complex organic compounds. In the pharmaceutical industry, it is often employed in the synthesis of active pharmaceutical ingredients (APIs). Additionally, Ethoxypropionitrile finds applications in the manufacture of specialty chemicals, including dyes, resins, and coatings. Its solubility properties also make it useful in formulations where a polar aprotic solvent is required. The compound's versatility ensures its continued relevance in various chemical industries.

Safety and Storage

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Ethoxypropionitrile is classified as harmful if swallowed or inhaled, and it can cause skin and eye irritation. Proper personal protective equipment (PPE), including gloves, goggles, and respiratory protection, should be used when handling the compound. Adequate ventilation is essential to minimize exposure to vapors. Storage of Ethoxypropionitrile should be in a cool, dry, well-ventilated area away from heat sources and open flames. Containers should be tightly sealed to prevent moisture absorption and contamination. In case of spills, absorbent materials should be used, and the area should be cleaned promptly to avoid environmental contamination.

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B2B Procurement Guide

When procuring Ethoxypropionitrile, buyers should prioritize suppliers with a proven track record of reliability and quality. It is essential to verify the purity of the compound, as impurities can affect its performance in chemical reactions. Bulk purchasing may offer cost savings, but storage capacity and shelf-life considerations should be evaluated. Potential buyers should also inquire about the supplier's compliance with safety and environmental regulations. Certificates of analysis (CoA) and material safety data sheets (MSDS) should be requested to ensure the product meets the required specifications. Comparing prices from multiple suppliers can help secure the best deal without compromising quality.

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