Ertapenem[2]
Overview
Ertapenem is a carbapenem antibiotic developed for its broad-spectrum activity against a wide range of bacteria. It is marketed under the brand name INVANZ and is commonly used in clinical settings to treat severe infections. Unlike other carbapenems, ertapenem has a longer half-life, allowing for once-daily dosing. Ertapenem is particularly effective against Gram-negative bacteria, including those producing extended-spectrum beta-lactamases (ESBLs). Its stability against many beta-lactamases makes it a valuable tool in combating resistant bacterial strains. The drug is typically administered intravenously or intramuscularly.
Physical and Chemical Properties
Ertapenem is a white to off-white powder with a molecular weight of 475.52 g/mol. It is soluble in water, which facilitates its formulation for intravenous or intramuscular administration. The compound is stable under recommended storage conditions but should be protected from light to prevent degradation. The molecular formula of ertapenem is C22H25N3O7S, reflecting its complex structure that includes a beta-lactam ring, essential for its antibacterial activity. The drug's stability in solution is pH-dependent, and it should be reconstituted with appropriate diluents to maintain efficacy.
Main Applications
Ertapenem is primarily used to treat bacterial infections such as intra-abdominal infections, skin and soft tissue infections, and urinary tract infections. It is also effective against community-acquired pneumonia and acute pelvic infections. The drug's broad-spectrum activity makes it a first-line option for empiric therapy in severe cases. In hospital settings, ertapenem is often reserved for infections caused by multidrug-resistant organisms. Its use is guided by susceptibility testing to ensure appropriate therapy and minimize the risk of resistance development. The drug is not effective against methicillin-resistant Staphylococcus aureus (MRSA) or Pseudomonas aeruginosa.
Safety and Storage
Ertapenem is generally well-tolerated, but it may cause adverse effects such as allergic reactions, gastrointestinal disturbances, and central nervous system effects like seizures in susceptible individuals. Patients with a history of penicillin or cephalosporin allergies should be monitored closely. The drug should be stored at 2-8°C and protected from light. Reconstituted solutions are stable for a limited time and should be used promptly. Proper disposal of unused medication is essential to prevent environmental contamination and antibiotic resistance.
B2B Procurement Guide
When procuring ertapenem, buyers should verify the supplier's compliance with Good Manufacturing Practices (GMP) to ensure product quality and safety. Documentation such as Certificates of Analysis (CoA) and stability data should be requested. Bulk purchases may offer cost savings, but storage capacity and shelf-life should be considered. Prices vary depending on the quantity and supplier, with reference ranges typically between $50 and $100 per gram. Buyers should also consider logistics, including cold chain requirements for transportation and storage. Establishing long-term relationships with reputable suppliers can ensure consistent quality and reliable supply.