Overview
Ergotamine Standard is a high-purity chemical reference material derived from ergot alkaloids, primarily used in pharmaceutical research and quality control. It serves as a benchmark for identifying and quantifying ergotamine in various formulations. As a standard, it ensures accuracy and consistency in analytical methods such as HPLC and mass spectrometry. Its precise molecular structure and known purity make it indispensable for regulatory compliance and laboratory validation processes.
Physical and Chemical Properties
Ergotamine Standard is characterized by its white to off-white crystalline appearance and high stability under controlled conditions. It has a molecular weight of 581.66 g/mol and a melting point of 212-214°C with decomposition. The compound is soluble in organic solvents like ethanol and methanol but has limited solubility in water. Its chemical stability is maintained when stored in cool, dry environments, protected from light and moisture.
Main Applications
The primary use of Ergotamine Standard is in pharmaceutical quality control, where it acts as a reference for ergot alkaloid analysis. It is critical for calibrating instruments and validating methods in drug testing laboratories. Additionally, it is employed in research settings to study the pharmacokinetics and toxicology of ergotamine derivatives. Its role extends to ensuring compliance with pharmacopeial standards such as USP and EP.
Safety and Storage
Ergotamine Standard requires careful handling due to its potential toxicity. Direct contact or inhalation should be avoided, and appropriate PPE, including gloves and lab coats, must be worn. Storage conditions are crucial for maintaining its integrity. It should be kept in a tightly sealed container at 2-8°C, away from light and humidity. Proper disposal methods must be followed to prevent environmental contamination.
B2B Procurement Guide
When procuring Ergotamine Standard, B2B buyers should prioritize suppliers with certifications like ISO or GMP. The certificate of analysis (CoA) is essential to verify purity and traceability. Bulk purchases may offer cost advantages, but buyers must ensure proper storage during transit. Lead times can vary, so planning ahead is recommended. Always confirm regulatory compliance for your region before purchase.
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