Overview
Equol standard is a high-purity chemical reference material primarily used in pharmaceutical and biochemical research. It is a chiral metabolite of daidzein, a soy isoflavone, and exists in two enantiomeric forms. The (-)-equol enantiomer is biologically active and commonly studied for its potential health benefits, including estrogenic and antioxidant properties. As a standard, equol is crucial for analytical methods such as HPLC and LC-MS, ensuring accuracy and reproducibility in research. It is also used in the development and quality control of dietary supplements and pharmaceuticals targeting hormone-related conditions.
Physical and Chemical Properties
Equol standard is a white to off-white crystalline powder with a molecular weight of 242.27 g/mol. It has a melting point range of 190-194°C and demonstrates good solubility in organic solvents like ethanol, methanol, and DMSO, but limited solubility in water. The compound is stable under recommended storage conditions but may degrade if exposed to light, heat, or moisture over extended periods. Its chemical structure includes a chroman skeleton with hydroxyl groups at positions 7 and 4', contributing to its polarity and reactivity. These properties make it suitable for chromatographic separation and spectroscopic analysis in laboratory settings.
Main Applications
Equol standard is widely used in pharmaceutical and nutraceutical research, particularly in studies involving estrogen receptors and menopause-related health. It serves as a reference material for quantifying equol levels in biological samples, such as blood or urine, to assess dietary isoflavone metabolism. In the dietary supplement industry, equol standard is essential for quality control, ensuring product consistency and potency. It also finds applications in preclinical studies exploring its potential anti-cancer, cardiovascular, and bone health benefits. Additionally, it is used in the development of enantiomer-specific assays due to its chiral nature.
Safety and Storage
Equol standard should be handled with care in laboratory environments. Avoid direct contact with skin, eyes, or respiratory pathways. Use appropriate PPE, including gloves, lab coats, and safety goggles. In case of accidental exposure, rinse thoroughly with water and seek medical advice if necessary. For long-term stability, store the compound in a tightly sealed container at 2-8°C, protected from light and moisture. Improper storage can lead to degradation, affecting its purity and performance as a reference material. Always check the material's condition before use and dispose of expired or contaminated samples according to local regulations.
B2B Procurement Guide
When procuring equol standard, prioritize suppliers with a proven track record in high-purity reference materials. Request certificates of analysis (CoA) to verify purity (typically ≥98%), CAS number (531-95-3), and enantiomeric purity if applicable. Compare prices from multiple vendors, as costs can vary significantly based on quantity and supplier reputation. Consider batch-to-batch consistency and the supplier's ability to provide technical support. For large-scale purchases, negotiate bulk discounts and confirm shipping conditions to ensure the product arrives in optimal condition. Establish a reliable supply chain to avoid disruptions in research or production workflows.
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