Overview
Alantolactone is a bioactive sesquiterpene lactone primarily extracted from the roots of Inula helenium, a plant traditionally used in herbal medicine. It belongs to the class of compounds known for their strong pharmacological properties, including antimicrobial and anti-inflammatory effects. Its unique structure makes it valuable in both pharmaceutical research and industrial applications. In traditional medicine, alantolactone has been used to treat respiratory and digestive ailments. Modern research explores its potential in cancer therapy due to its ability to inhibit tumor growth. Its role in organic synthesis as a chiral building block further expands its industrial relevance.
Physical and Chemical Properties
Alantolactone is characterized by its white crystalline form and distinct camphor-like odor. It has a melting point of 74–77°C and is soluble in organic solvents like ethanol and chloroform but not in water. The compound’s stability under normal storage conditions makes it suitable for long-term use. Its molecular structure includes a lactone ring, which contributes to its reactivity and biological activity. The compound exhibits photostability but may degrade under prolonged exposure to high temperatures or acidic/basic conditions, necessitating careful handling during storage and processing.
Main Applications
The pharmaceutical industry leverages alantolactone for its antitumor and antimicrobial properties. It is studied for its potential to induce apoptosis in cancer cells and as an ingredient in topical anti-inflammatory formulations. Traditional medicine systems, particularly in Asia and Europe, utilize it for treating bronchitis and parasitic infections. In organic synthesis, alantolactone serves as a precursor for complex molecules due to its chiral centers. It is also used in fragrances and flavorings, albeit in limited quantities, owing to its strong aroma. Research continues to explore its applications in drug development and agrochemicals.
Safety and Storage
Alantolactone requires cautious handling due to its potential to cause skin and eye irritation. Personal protective equipment (PPE) such as gloves and goggles is recommended. Inhalation of dust should be avoided by working in fume hoods or well-ventilated areas. Storage conditions include keeping the compound in airtight containers, protected from light and moisture, at temperatures below 25°C. Prolonged exposure to humid environments may lead to degradation. Suppliers typically provide material safety data sheets (MSDS) for reference.
B2B Procurement Guide
When procuring alantolactone, prioritize suppliers with ISO or GMP certifications to ensure quality. Key specifications to verify include purity (≥98% by HPLC), absence of heavy metals, and batch-to-batch consistency. Request certificates of analysis (CoA) for each shipment. Bulk purchases (kilogram-scale) often reduce costs by 10–30%. Consider lead times, as natural extraction methods may delay availability. For pharmaceutical use, ensure compliance with regional regulatory standards (e.g., USP, EP). Sample testing before large orders is advisable.
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