Echinacoside

Updated: 2026-08-17

Overview

Echinacoside is a bioactive phenylethanoid glycoside primarily extracted from Echinacea purpurea and Cistanche deserticola. It has gained attention for its multifaceted pharmacological properties, including antioxidant, anti-inflammatory, and neuroprotective effects. The compound is widely used in traditional Chinese medicine and modern herbal supplements. Research indicates echinacoside may support cognitive health by reducing oxidative stress and inhibiting neurodegenerative pathways. Its stability and solubility profile make it suitable for oral and topical formulations, though bioavailability can vary depending on the delivery system.

Physical and Chemical Properties

Echinacoside is a white crystalline powder with a molecular weight of 786.73 g/mol. It exhibits moderate solubility in polar solvents like water and methanol but is less soluble in non-polar solvents. The compound is stable under acidic conditions but may degrade under prolonged exposure to heat or UV light. Its chemical structure includes a phenylpropanoid core linked to glucose and rhamnose units, contributing to its biological activity. Analytical methods such as HPLC and LC-MS are commonly used to quantify its purity, which typically exceeds 98% in pharmaceutical-grade extracts.

Main Applications

In the pharmaceutical industry, echinacoside is incorporated into formulations targeting neurodegenerative diseases (e.g., Alzheimer’s) due to its ability to cross the blood-brain barrier. Nutraceutical companies use it in immune-boosting supplements, often combined with other botanicals like Echinacea or ginseng. The cosmetic industry leverages its antioxidant properties in anti-aging serums and creams. Additionally, it serves as a reference standard in quality control for herbal extracts. Emerging applications include functional foods and beverages aimed at cognitive health.

Safety and Storage

Echinacoside is non-toxic at typical dosages but should be handled with standard laboratory precautions to avoid inhalation or eye contact. Storage at 2-8°C in airtight containers prevents degradation. Suppliers often provide stability data under accelerated conditions (e.g., 40°C/75% RH for 6 months). Regulatory status varies by region; in the U.S., it is generally regarded as safe (GRAS) for dietary supplements, while the EU may require Novel Food authorization for certain applications. Always confirm compliance with local regulations before procurement.

B2B Procurement Guide

When sourcing echinacoside, prioritize suppliers with ISO 9001 or GMP certification to ensure quality consistency. Key specifications include purity (≥98% by HPLC), residual solvents (meeting ICH guidelines), and heavy metal content (<10 ppm). Bulk pricing is often negotiable for orders exceeding 10 kg. Consider partnering with manufacturers specializing in plant-derived actives, such as those in China or Germany. Sample testing via third-party labs is recommended to validate claims. Lead times typically range from 2-6 weeks, depending on customization needs.