Overview
Echinoside A (海胆灵) is a bioactive triterpenoid saponin isolated from sea urchins, particularly of the Strongylocentrotus and Anthocidaris species. It serves as a reference standard in pharmaceutical and biochemical research due to its structural uniqueness and therapeutic potential. The compound has gained attention for its role in marine drug discovery pipelines. As a high-value specialty chemical, Echinoside A is typically supplied in milligram quantities with purity levels exceeding 95%. Its molecular structure features a complex aglycone core with multiple sugar moieties, contributing to both its biological activity and research utility in structure-activity relationship studies.
Physical and Chemical Properties
Echinoside A presents as a crystalline or amorphous powder with moderate stability under controlled conditions. Its solubility profile makes it suitable for biological assays requiring organic solvents, though formulation challenges exist for aqueous applications. The compound exhibits characteristic UV absorption at 205-210 nm, useful for analytical quantification. The glycosidic bonds in Echinoside A are sensitive to acidic hydrolysis, requiring neutral pH conditions during handling. Thermal gravimetric analysis shows decomposition beginning at 210°C, confirming the need for low-temperature storage. Mass spectrometry typically reveals [M+Na]+ and [M+K]+ adducts in positive ion mode due to its glycosylated structure.
Main Applications
In pharmaceutical research, Echinoside A is primarily investigated for its antitumor properties, particularly in inhibiting tumor angiogenesis and metastasis through modulation of NF-κB and MAPK pathways. Current studies focus on its potential as a lead compound for colorectal and breast cancer therapeutics. The compound also serves as a biochemical tool in marine natural product chemistry, helping researchers understand structure-bioactivity relationships in saponin compounds. Some cosmetic applications explore its anti-inflammatory effects for skincare formulations, though these remain in experimental stages. As a reference standard, it's essential for quality control in marine-derived drug development.
Safety and Storage
As a bioactive compound, Echinoside A requires careful handling per GHS Category 3 guidelines. Use nitrile gloves and safety goggles when weighing powder, and conduct operations in a fume hood to prevent airborne dispersion. Spills should be contained with inert absorbent materials and disposed as chemical waste. Long-term storage demands airtight containers with desiccant packs at -20°C, with aliquoting recommended to minimize freeze-thaw cycles. Under these conditions, the material typically maintains stability for 2-3 years. Shipping requires temperature-controlled packaging with sufficient insulation for international transit.
B2B Procurement Guide
When sourcing Echinoside A, prioritize suppliers with demonstrated expertise in marine natural products and ISO-certified analytical capabilities. Key procurement criteria should include batch-specific HPLC purity reports (≥95%), residual solvent analysis, and microbial contamination testing. For research institutions, consider collaborating with specialized marine biotechnology firms that offer custom isolation services to ensure compound authenticity. Bulk purchases (100mg+) may qualify for tiered pricing, but validate scalability of extraction methods. Lead times often range 4-8 weeks due to complex purification processes, necessitating advanced planning for critical projects.
Related Manufacturers
- 主营：海胆灵、白蜡树素、百两金素、半齿泽兰素
- 主营：天然化合物、分析试剂、细胞实验、中药标准品、标准品对照品、标准品、动物实验、中药提取物、单体化合物、科研实验用
- 主营：ELISA试剂盒、PCR试剂盒、生化试剂盒、脂蛋白、关基因、亲环素、钾通道、列抗体、ntp溶液、蛋白酶、脑蛋白、病毒抗、蛋白质、239抗体、dtt溶液、科研试剂
- 主营：芦丁标准品、对照品标准品、酒渣碱、异常山乙素
- 主营：对照品、当归酸酐、佛手柑内酯、标准品、新当归内酯、补骨脂甲素、补骨脂乙素、羟基芍药苷、阿魏酸松柏酯、水合氧化前胡素、豆甾醇葡萄糖苷
- 主营：莪术二酮、人参皂苷rc、自制对照品、标准品、淫羊藿次苷
- 主营：新海胆灵A、白僵菌素、薯蓣皂苷
- 主营：细辛脂素、百两金素、延胡索乙素、标准品、桃叶珊瑚苷、脱氢紫堇碱