Overview
Dynorphin A is a 17-amino acid opioid peptide derived from the prodynorphin precursor. It is a member of the dynorphin family and is widely distributed in the central nervous system. Dynorphin A primarily binds to kappa-opioid receptors (KOR), influencing pain perception, stress responses, and reward pathways. This peptide is of significant interest in neuroscience due to its role in modulating neural circuits and its potential implications in addiction, depression, and chronic pain conditions. Research-grade Dynorphin A is commonly used in laboratory settings to study its physiological and pharmacological effects.
Physical and Chemical Properties
Dynorphin A is a white to off-white powder with a molecular weight of approximately 2149.45 g/mol. It is soluble in water and acetic acid, making it suitable for various experimental preparations. The peptide is sensitive to degradation by proteases and requires careful handling to maintain stability. Its primary sequence includes tyrosine, glycine, and other amino acids, contributing to its receptor-binding affinity. The peptide's stability is highly dependent on storage conditions, requiring temperatures of -20°C or lower to prevent decomposition.
Main Applications
Dynorphin A is primarily used in neuroscience research to investigate its role in pain modulation, stress responses, and addiction. Studies often focus on its interaction with kappa-opioid receptors and its effects on dopamine release in the brain. Additionally, it is employed in neuroendocrine research to understand its influence on hormone regulation. Due to its potent biological activity, Dynorphin A is also studied for potential therapeutic applications, though clinical use remains experimental.
Safety and Storage
Dynorphin A should be handled with caution, as it may cause irritation upon contact with skin or mucous membranes. Researchers are advised to use gloves, goggles, and lab coats when working with this peptide. Proper storage is critical to maintain its stability. It should be kept at -20°C in a dry environment, protected from light and moisture. Lyophilized Dynorphin A is typically more stable than solutions, which should be prepared fresh or stored frozen for short-term use.
B2B Procurement Guide
When procuring Dynorphin A for research purposes, verify the supplier's reputation and the product's purity (typically ≥95% by HPLC). Custom synthesis services are available for specific experimental needs, but standard research-grade quantities are commonly stocked by biochemical suppliers. Pricing varies based on purity and quantity, with bulk purchases often available at discounted rates. Ensure compliance with local regulations regarding the handling and shipment of bioactive peptides.
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