Overview
DSPE-SS- is a modified phospholipid derivative featuring a disulfide (SS) bond linker, making it a critical component in advanced drug delivery systems. Its structure combines the hydrophobic distearoyl chains of DSPE with a redox-sensitive disulfide bridge, enabling controlled release of encapsulated therapeutics under reducing environments, such as those found in tumor tissues or intracellular compartments. This compound is widely utilized in pharmaceutical and biomedical research due to its ability to form stable liposomes or micelles. Its biocompatibility and responsiveness to biological stimuli make it a preferred choice for targeted therapy and nanotechnology applications.
Physical and Chemical Properties
DSPE-SS- typically appears as a white to off-white powder with a molecular weight of approximately 820.18 g/mol. It is soluble in organic solvents like chloroform and methanol but exhibits limited solubility in aqueous solutions unless formulated into nanostructures such as liposomes. The disulfide bond in DSPE-SS- is its defining feature, providing redox-sensitive cleavage under reducing conditions (e.g., high glutathione levels in cancer cells). This property allows for triggered drug release, enhancing therapeutic efficacy while minimizing off-target effects. The compound’s stability under standard storage conditions (-20°C, protected from light) ensures long-term usability.
Main Applications
DSPE-SS- is primarily employed in the development of stimuli-responsive drug delivery systems. Its disulfide linkage enables the design of liposomes or polymeric micelles that release payloads selectively in reducing environments, such as tumor microenvironments or intracellular spaces. This targeted approach improves drug bioavailability and reduces systemic toxicity. Beyond oncology, DSPE-SS- is used in gene delivery, vaccine adjuvants, and diagnostic imaging agents. Its versatility in forming nanostructures with tunable properties makes it a valuable tool for researchers exploring next-generation nanomedicines.
Safety and Storage
DSPE-SS- should be handled with standard laboratory precautions, including gloves and protective eyewear, to avoid skin or eye contact. Inhalation of powder should be prevented by working in a fume hood. The compound is not classified as highly hazardous, but proper handling minimizes risks. For storage, DSPE-SS- must be kept at -20°C in a tightly sealed container, protected from moisture and light. Prolonged exposure to ambient conditions may degrade the disulfide bond, compromising its functionality. Always verify material integrity before use in critical experiments.
B2B Procurement Guide
When procuring DSPE-SS-, prioritize suppliers specializing in high-purity phospholipids for research or pharmaceutical use. Key considerations include batch-to-batch consistency, purity (>95% by HPLC), and documentation (e.g., COA, MSDS). Bulk purchases may offer cost savings, but ensure proper storage capacity to maintain stability. For specialized applications (e.g., GMP-grade materials), collaborate with vendors offering custom synthesis or scale-up services. Pricing varies widely based on quantity and purity, with reference ranges of $500-$1,500 per gram. Request samples for preliminary testing to confirm compatibility with your formulation requirements.
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