Overview
Doxifluridine is a fluoropyrimidine derivative that serves as a prodrug for 5-fluorouracil (5-FU), a widely used chemotherapeutic agent. Developed to improve the bioavailability and reduce the side effects of 5-FU, doxifluridine is metabolized in vivo to release the active compound. It is primarily used in the treatment of gastrointestinal cancers, including colorectal and gastric cancers, as well as breast cancer. The drug is administered orally or intravenously, depending on the clinical protocol. Its development marked a significant advancement in cancer therapy, offering a more targeted approach to delivering 5-FU. Doxifluridine is marketed under various brand names, including Furtulon, and is available in several formulations.
Physical and Chemical Properties
Doxifluridine is a white to off-white crystalline powder with a molecular weight of 246.19 g/mol. It is soluble in water and dimethyl sulfoxide (DMSO), which facilitates its formulation into various pharmaceutical preparations. The compound has a melting point of approximately 190-194°C, indicating its stability under standard conditions. The molecular structure of doxifluridine includes a fluoropyrimidine core, which is essential for its antineoplastic activity. The compound's solubility and stability make it suitable for oral and intravenous administration, ensuring consistent pharmacokinetics. Its ability to convert to 5-FU in vivo is a key feature, enabling localized release of the active agent in tumor tissues.
Main Applications
Doxifluridine is primarily used in the treatment of gastrointestinal cancers, such as colorectal and gastric cancers, where it has shown efficacy in clinical trials. It is also employed in the management of breast cancer, particularly in cases where 5-FU-based regimens are indicated. The drug's prodrug nature allows for targeted delivery, minimizing systemic toxicity. In addition to its standalone use, doxifluridine is often combined with other chemotherapeutic agents to enhance therapeutic outcomes. Its oral bioavailability makes it a convenient option for outpatient treatment, improving patient compliance. The drug's application in palliative care has also been explored, offering symptomatic relief in advanced cancer cases.
Safety and Storage
Doxifluridine is classified as a hazardous substance and requires careful handling to prevent exposure. Personal protective equipment (PPE), including gloves and masks, should be worn when handling the compound. Ingestion or inhalation can lead to serious health effects, including bone marrow suppression and gastrointestinal toxicity. Proper storage conditions are essential to maintain the drug's stability. Doxifluridine should be stored in a cool, dry place, away from direct light, at temperatures below 25°C. Containers should be tightly sealed to prevent moisture absorption and degradation. Disposal should comply with local regulations for hazardous pharmaceutical waste.
B2B Procurement Guide
When procuring doxifluridine, B2B buyers should prioritize suppliers with certification from recognized pharmaceutical authorities. Verification of the compound's purity, typically through high-performance liquid chromatography (HPLC), is essential to ensure compliance with pharmacopeia standards. Buyers should also request batch-specific certificates of analysis (CoA). Price negotiations should consider the quantity ordered, with bulk purchases often attracting discounts. Lead times can vary depending on supplier availability, so advance planning is recommended. Buyers should also assess the supplier's track record in handling and shipping hazardous materials to ensure safe delivery.
Related Manufacturers
- 主营：木质醛、酮锌吡、褪黑素、甘油酯、粘蛋白、薄荷脑、苯氨基、苹果酸、三羟基、皮粉五、甲基蓝、生根粉、动力精、薄荷酮、二羟基、3α羟基、萘酰胺、胶粘剂、磷酸三、嗪二酮、氨酸钾、嘧啶酮、氨酸镁、407环氧、酸cas号
- 主营：去氧氟尿甙、白蜡树素、百两金素、半齿泽兰素
- 主营：去氧氟尿甙、白僵菌素、薯蓣皂苷
- 主营：蛋白酶、淀粉酶、果胶酶、胰酵素、崩溃酶、蜗牛酶、乳糖酶、肌酸激酶、葡球菌酶、绿色木霉、心肌黄酶、亮抑酶肽、纤维素酶、木聚糖酶、-glucosidase、亮抑肽酶、硫代辅酶、枯草杆菌、羧化辅酶、氯化酵素、脆壁质酶、细胞溶解酶、乙醇脱氢酶、透明质酸酶、氯化溶菌酶
- 主营：酒渣碱、异常山乙素、芦丁标准品、去氧氟尿甙、对照品标准品
- 主营：龙胆苦苷、粉防己碱、獐牙菜苦苷、去氧氟尿甙、杨梅苷
- 主营：异硫氰酸胍、三(羟甲基)氨基甲烷tris、二硫苏糖醇(DTT)、β巯基乙醇、蛋白酶k、焦碳酸二乙酯DEPC、EDTA二钠、十二烷基苯磺酸钠
- 主营：l谷氨酸、d谷氨酸、l亮氨酸、去氧氟尿甙3094095、人补体7、人补体1q、largininehcl、人钙调素、人雌三醇、人唾液酸、人多巴胺、人强啡肽、bocl丙氨酸、l异亮氨酸、猪d二聚体、d天冬氨酸、l天冬氨酸、人白三烯c4、猪白介素12、pcdh1试剂盒、elisa试剂盒、dl半胱氨酸、人磷脂酶a2、dl谷氨酰胺、人降钙素原、人轮状病毒
- 主营：人流感、m117-500g、脂蛋白、去氧氟尿甙、0189-100g、猪睾酮、人胰岛、赖氨酸、柚皮素、人新生、人蛋白、e122-100g、柚皮苷、人戊肝、磷脂酶、蛋白酶、fishelisa、皂苷rg3、酮戊二、人轮状、人胆酸、j636-100g、胰多肽、厚朴酚、噻唑蓝、甜菊苷