Overview
Benzamidine, also known as benzenecarboximidamide, is an organic compound with the molecular formula C7H8N2. It is widely recognized for its role as a competitive inhibitor of serine proteases, making it valuable in biochemical and pharmaceutical research. The compound is typically available as a white to off-white crystalline powder and is soluble in water and ethanol. Benzamidine's importance in scientific research stems from its ability to inhibit enzymes like trypsin and thrombin, which are crucial in various biological processes. Its applications extend to drug development, where it is used to study enzyme mechanisms and develop therapeutic agents.
Physical and Chemical Properties
Benzamidine has a molecular weight of 120.15 g/mol and a melting point of 78-80 °C. It appears as a white to off-white crystalline powder and is soluble in water and ethanol, which makes it versatile for laboratory use. The compound is stable under normal storage conditions but should be kept away from direct sunlight and moisture. One of the key chemical properties of benzamidine is its ability to act as a competitive inhibitor for serine proteases. This property is leveraged in various biochemical assays and research applications. Its solubility in common laboratory solvents further enhances its utility in scientific experiments.
Main Applications
Benzamidine is primarily used in biochemical research as a competitive inhibitor of serine proteases such as trypsin and thrombin. These enzymes play critical roles in processes like blood clotting and digestion, making benzamidine a valuable tool for studying these mechanisms. In the pharmaceutical industry, benzamidine is employed in the synthesis of drugs targeting protease-related diseases. Its inhibitory properties are also explored in the development of therapeutic agents for conditions like thrombosis and inflammation. Additionally, it is used in laboratory settings for protein purification and enzyme inhibition studies.
Safety and Storage
Benzamidine may cause skin and eye irritation upon contact, so it is essential to handle it with appropriate protective equipment such as gloves and goggles. In case of exposure, rinse affected areas thoroughly with water and seek medical attention if necessary. For storage, benzamidine should be kept in a cool, dry place away from direct sunlight. Properly sealed containers are recommended to prevent moisture absorption and degradation. Long-term stability can be ensured by storing the compound in a controlled environment with minimal temperature fluctuations.
B2B Procurement Guide
When procuring benzamidine for B2B purposes, it is crucial to verify the purity and quality of the compound. Suppliers should provide certificates of analysis (CoA) to confirm the product's specifications. Pricing typically ranges from $50 to $100 per 100g, depending on purity and supplier. Bulk purchases may offer cost advantages, but buyers should ensure that storage facilities meet the required conditions to maintain product integrity. Additionally, consider suppliers with a proven track record in chemical distribution to guarantee reliable and consistent quality.
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