Overview
Dimethyl Suberimidate (DMS) is a bifunctional crosslinking agent primarily used in biochemical and biomedical research. It is known for its ability to react with primary amines, making it valuable for protein crosslinking and antibody conjugation. DMS is widely utilized in labs for stabilizing protein structures and studying protein-protein interactions. Its specificity and efficiency in forming covalent bonds between amine groups make it a preferred choice in various research applications.
Physical and Chemical Properties
DMS appears as a white crystalline powder with a molecular weight of 198.26 g/mol. It is soluble in water and most organic solvents, facilitating its use in aqueous and non-aqueous environments. The compound has a melting point around 120-122°C and reacts specifically with primary amines under mild conditions. Its stability and reactivity profile make it suitable for controlled crosslinking experiments in biochemical studies.
Main Applications
DMS is extensively used in protein crosslinking to study molecular interactions and stabilize protein structures. It is also employed in antibody conjugation for diagnostic and therapeutic purposes. In addition, DMS finds applications in immobilizing enzymes and preparing affinity chromatography matrices. Its versatility in forming stable covalent bonds makes it indispensable in advanced biochemical research.
Safety and Storage
DMS should be handled with care, using gloves and protective eyewear to avoid skin and eye contact. Inhalation of dust should be prevented by working in a well-ventilated area or using a fume hood. Store DMS in a cool, dry place, away from moisture and direct sunlight. Proper storage ensures the compound's stability and extends its shelf life for research use.
B2B Procurement Guide
When procuring DMS, verify the supplier's purity certifications and handling instructions. Bulk purchases may offer cost savings, but ensure proper storage conditions are maintained. Consider suppliers with a track record in biochemical reagents for reliable quality. Price ranges vary, so compare options based on purity, quantity, and additional services like technical support.
Related Manufacturers
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