Dihydrotestosterone

Updated: 2026-09-11

Overview

Dihydrotestosterone (DHT) is a biologically active metabolite of testosterone, formed by the action of the enzyme 5α-reductase. It is a key androgen responsible for the development of male secondary sexual characteristics, such as facial hair growth, deepening of the voice, and muscle mass. DHT binds more strongly to androgen receptors than testosterone, making it a potent mediator of androgen effects in the body. In addition to its physiological roles, DHT is used in medical treatments and research, particularly in studies related to androgenetic alopecia (male-pattern baldness) and benign prostatic hyperplasia (BPH). Its synthetic analogs are also explored for therapeutic applications.

Physical and Chemical Properties

DHT is a steroid hormone with a molecular weight of 290.44 g/mol. It appears as a white to off-white crystalline powder and is soluble in organic solvents like ethanol and dimethyl sulfoxide (DMSO), but has limited solubility in water. The compound has a melting point of approximately 178-182°C, indicating its stability under standard conditions. Chemically, DHT is derived from testosterone via reduction of the double bond in the A-ring by 5α-reductase. This structural modification enhances its binding affinity to androgen receptors, making it a more potent androgen than its precursor. Its stability and solubility properties are critical for formulation in pharmaceutical applications.

Main Applications

DHT is primarily used in medical and research settings. Clinically, it is investigated for conditions like androgen deficiency, where testosterone therapy is insufficient. It is also studied in the context of hair loss treatments, as DHT is a major contributor to androgenetic alopecia. Additionally, DHT plays a role in prostate health research, particularly in understanding benign prostatic hyperplasia (BPH) and prostate cancer. In the pharmaceutical industry, DHT and its derivatives are utilized in hormone replacement therapies and as reference standards in biochemical assays. Its applications extend to veterinary medicine and performance-enhancing research, though regulatory restrictions apply.

Safety and Storage

DHT is a potent hormone and should be handled with caution to avoid unintended exposure. Personal protective equipment (PPE), including gloves and lab coats, is recommended when working with the compound. Inhalation or skin contact should be minimized, as DHT can exert systemic hormonal effects. For storage, DHT should be kept in a tightly sealed container at -20°C, protected from light and moisture to prevent degradation. Long-term stability is enhanced under inert gas (e.g., argon) to avoid oxidation. Proper disposal methods should follow local regulations for hormonal substances.

B2B Procurement Guide

When procuring DHT for B2B purposes, prioritize suppliers with verified credentials and compliance with regulatory standards (e.g., FDA, DEA). Key considerations include purity (typically ≥98% by HPLC/GC-MS), packaging (e.g., amber vials for light-sensitive storage), and documentation (e.g., certificates of analysis). Bulk orders may require special permits due to DHT's classification as a controlled substance in some regions. Pricing varies based on quantity and purity, with research-grade material commonly ranging from $50-$500 per gram. Establish clear agreements on lead times, shipping conditions (cold chain for stability), and after-sales support.

Basic Info

Chinese Name: 二氢睾酮
English Name: Dihydrotestosterone
Synonyms: DHT, Androstanolone, 5α-Dihydrotestosterone
CAS Number: 521-18-6
Molecular Formula: C19H30O2
Molecular Weight: 290.44 g/mol
Appearance: White to off-white crystalline powder
Density: N/A
Melting Point: Approximately 178-182°C
Boiling Point: N/A
Solubility: Soluble in organic solvents (e.g., ethanol, DMSO); poorly soluble in water
Storage Conditions: Store at -20°C in a tightly sealed container, protected from light and moisture
Key Properties: Potent androgen, high affinity for androgen receptors, derived from testosterone via 5α-reductase
Main Applications: Medical treatments (e.g., androgen deficiency, research on prostate health, hair loss), pharmaceuticals, biochemical research
Safety Notes: Handle with care; potential hormonal effects. Use personal protective equipment (PPE). Avoid inhalation or skin contact.
Reference Price Range: Varies by purity and quantity; commonly $50-$500 per gram for research-grade (for reference only)
Procurement Notes: Verify supplier credentials, purity (HPLC/GC-MS), and regulatory compliance (e.g., DEA, FDA). Bulk orders may require special permits.