Overview
Difluoroacetone is an organofluorine compound with the formula C3H4F2O. It is a colorless liquid with a pungent odor, primarily used as an intermediate in chemical synthesis. Due to its reactive difluoromethyl group, it is valuable in pharmaceuticals and agrochemicals. The compound is synthesized through fluorination of acetone derivatives. Its reactivity makes it a versatile building block for introducing fluorine atoms into larger molecules, enhancing their biological activity or stability.
Physical and Chemical Properties
Difluoroacetone is a volatile liquid with a boiling point of 75-77°C and a density of approximately 1.15 g/cm³. It is soluble in common organic solvents like ethanol, ether, and acetone but has limited water solubility. Its key chemical property is the reactivity of the difluoromethyl group, which participates in nucleophilic and electrophilic reactions. The compound is flammable and should be handled with care to avoid ignition or decomposition under heat.
Main Applications
Difluoroacetone is widely used in pharmaceutical research to synthesize fluorinated analogs of bioactive molecules. Fluorination often improves drug metabolism and binding affinity. In agrochemicals, it serves as a precursor for herbicides and pesticides. Additionally, it is employed in specialty chemical production, such as fluorinated polymers and coatings, where its reactivity enables tailored material properties.
Safety and Storage
Difluoroacetone is flammable and toxic upon inhalation or skin contact. Proper PPE (gloves, goggles, respirators) is mandatory. Store in sealed containers in a cool, ventilated area away from oxidizers. Spills should be neutralized with inert absorbents and disposed of as hazardous waste. Regulatory compliance (e.g., OSHA, REACH) is essential for workplace safety and environmental protection.
B2B Procurement Guide
Buyers should prioritize suppliers with ISO certification and batch-specific COAs (Certificates of Analysis) to ensure purity (≥98%). Bulk orders (25kg+ drums) typically offer cost advantages. Logistics must account for flammability—shipments require hazardous material labeling. Negotiate contracts with flexible delivery terms to accommodate fluctuating demand in pharmaceutical and agrochemical industries.
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