Diethyl phenyl ethyl malonate
Overview
Diethyl Phenyl Ethyl Malonate is an organic ester compound widely used in pharmaceutical and fine chemical industries. It serves as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs) and specialty chemicals. The compound is known for its stability and versatility in organic reactions. Its molecular structure includes a phenyl group and an ethyl group attached to a malonate core, making it useful for further chemical modifications. The ester functional groups provide reactivity for condensation and substitution reactions, which are common in drug synthesis.
Physical and Chemical Properties
Diethyl Phenyl Ethyl Malonate is a colorless to pale yellow liquid with a mild ester-like odor. It has a molecular weight of 264.32 g/mol and a density ranging between 1.05 and 1.10 g/cm³. The compound is soluble in common organic solvents such as ethanol, ether, and acetone but is insoluble in water. It is relatively stable under normal storage conditions but may decompose when exposed to high temperatures or strong acids/bases. The boiling point is approximately 300-310°C, and it does not have a well-defined melting point due to its liquid state at room temperature.
Main Applications
The primary use of Diethyl Phenyl Ethyl Malonate is as an intermediate in pharmaceutical synthesis. It is employed in the production of APIs, particularly in the development of cardiovascular and central nervous system drugs. Its malonate core allows for further functionalization, making it valuable in multi-step synthesis processes. In addition to pharmaceuticals, the compound is used in fine chemical synthesis for creating specialty chemicals, fragrances, and agrochemicals. Its reactivity and stability make it a preferred choice for complex organic transformations.
Safety and Storage
Diethyl Phenyl Ethyl Malonate should be handled with care to avoid health risks. Use gloves, protective eyewear, and adequate ventilation when working with the compound. Avoid direct skin contact or inhalation, as it may cause irritation or allergic reactions. Store the compound in a cool, dry place away from direct sunlight and moisture. Keep containers tightly sealed to prevent contamination or evaporation. Follow local regulations for disposal and ensure compliance with environmental safety standards.
B2B Procurement Guide
When procuring Diethyl Phenyl Ethyl Malonate, verify the CAS number (20320-59-6) and purity specifications with the supplier. Request a Certificate of Analysis (CoA) to confirm quality and composition. Reputable suppliers should provide material safety data sheets (MSDS) and comply with international safety standards. Consider bulk purchasing for cost savings, but ensure proper storage conditions are maintained. Compare prices from multiple suppliers, as the reference range is approximately $50-$100 per kg. Evaluate supplier reliability, lead times, and customer reviews before finalizing a purchase.
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