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Diethoxymethane Solution

Updated: 2026-07-29

Overview

Diethoxymethane solution, also known as formaldehyde diethyl acetal, is a colorless, volatile liquid with a characteristic ether-like odor. It is commonly used as a solvent in various industrial applications due to its excellent solubility properties. The compound is synthesized through the reaction of formaldehyde with ethanol in the presence of an acid catalyst. Diethoxymethane is highly flammable and should be handled with care. Its primary use is in the pharmaceutical and perfume industries, where it serves as a versatile solvent for organic synthesis. The solution is also employed in the production of resins and coatings.

Physical and Chemical Properties

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Diethoxymethane is a low-viscosity liquid with a density of 0.831 g/cm³ at 20°C. It has a boiling point range of 88-90°C and a melting point of -66°C. The compound is soluble in water, ethanol, and ether, making it a useful solvent for a wide range of chemical reactions. Its molecular formula is C5H12O2, and it has a molecular weight of 104.15 g/mol. The solution is highly volatile and flammable, requiring careful storage and handling. It exhibits a characteristic ether-like odor, which can be a useful identifier in laboratory settings.

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Main Applications

Diethoxymethane solution is primarily used as a solvent in the pharmaceutical industry, where it facilitates the synthesis of various active pharmaceutical ingredients (APIs). It is also a key component in the production of perfumes and fragrances due to its ability to dissolve a wide range of organic compounds. In addition, the solution is employed in the manufacture of resins, coatings, and adhesives. Its volatility and solubility properties make it an ideal choice for applications requiring rapid evaporation and uniform distribution of solutes. The compound is also used in organic synthesis as a protecting group for aldehydes and ketones.

Safety and Storage

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Diethoxymethane solution is highly flammable and should be stored in a cool, dry, well-ventilated area away from heat sources and open flames. Proper grounding of containers is essential to prevent static discharge, which could ignite the vapor. Personal protective equipment (PPE), including gloves, goggles, and respirators, should be worn when handling the solution. Avoid inhalation, skin contact, and ingestion. In case of exposure, seek immediate medical attention. Spills should be contained and cleaned up using absorbent materials, and contaminated areas should be ventilated thoroughly.

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B2B Procurement Guide

When procuring diethoxymethane solution, it is crucial to verify the CAS number (462-95-3) and purity specifications to ensure the product meets your requirements. Reputable suppliers should provide material safety data sheets (MSDS) and comply with relevant safety and regulatory standards. Prices typically range from $20 to $50 per liter, depending on purity and supplier. Bulk purchases may offer cost savings. Ensure that the supplier has proper storage and transportation facilities to maintain the integrity of the product. It is also advisable to establish a long-term relationship with a reliable supplier to ensure consistent quality and availability.

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