Diethoxyacetaldehyde

Updated: 2026-07-21

Overview

Glycolaldehyde Diethyl Acetal is a specialized chemical compound primarily used in organic synthesis. It serves as a protecting group for glycolaldehyde, a key intermediate in carbohydrate chemistry. The compound is characterized by its stability under neutral conditions and its ability to hydrolyze under acidic conditions, making it valuable in controlled reactions. In industrial settings, Glycolaldehyde Diethyl Acetal is often utilized in pharmaceutical and fine chemical synthesis. Its role as a protecting group ensures the selective modification of other functional groups in complex molecular structures.

Physical and Chemical Properties

Glycolaldehyde Diethyl Acetal is a colorless to pale yellow liquid with a mild odor. It has a molecular weight of 134.18 g/mol and a density ranging between 0.95-0.97 g/cm³. The compound is soluble in most organic solvents, including ethanol, ether, and acetone, but exhibits limited solubility in water. Its boiling point is approximately 170-175°C, and it remains stable under normal storage conditions. However, it hydrolyzes in the presence of acids, releasing glycolaldehyde and ethanol. This property is exploited in synthetic chemistry for controlled deprotection reactions.

Main Applications

The primary application of Glycolaldehyde Diethyl Acetal is in organic synthesis, where it acts as a protecting group for glycolaldehyde. This is particularly useful in the synthesis of complex carbohydrates, pharmaceuticals, and fine chemicals. By temporarily masking the reactive aldehyde group, chemists can perform selective reactions on other parts of the molecule. Additionally, the compound is used in the production of fragrances and flavoring agents. Its ability to hydrolyze under controlled conditions makes it a versatile tool in multi-step synthetic processes.

Safety and Storage

Glycolaldehyde Diethyl Acetal is classified as an irritant to skin and eyes. Proper personal protective equipment (PPE), including gloves and safety goggles, should be worn when handling the compound. In case of contact, affected areas should be rinsed immediately with plenty of water. The compound should be stored in a cool, dry, well-ventilated area away from heat sources and open flames. Containers must be tightly sealed to prevent moisture absorption and degradation. Spills should be contained and cleaned up promptly using inert absorbent materials.

B2B Procurement Guide

When procuring Glycolaldehyde Diethyl Acetal, buyers should verify the CAS number (621-64-7) and purity specifications to ensure the product meets their requirements. Reputable suppliers typically provide certificates of analysis (CoA) detailing the compound's purity and impurity profile. The reference price range is approximately $50-$100 per kg, depending on purity and supplier. Bulk purchases may qualify for discounts. Buyers should also consider logistical factors, such as shipping conditions and lead times, to ensure timely delivery.