Overview
Dienolone Acetate is a crucial steroid intermediate derived from diosgenin or solasodine. It serves as a building block for synthesizing corticosteroids, contraceptives, and other steroid-based pharmaceuticals. The compound’s diene structure at positions 5,16 makes it highly reactive for further chemical modifications. Industrially, it is produced via microbial fermentation or chemical synthesis, with strict quality controls to ensure purity. Its role in steroid synthesis has made it a staple in pharmaceutical manufacturing, particularly for anti-inflammatory and hormonal therapies.
Physical and Chemical Properties
Dienolone Acetate is characterized by its white crystalline form and stability under controlled conditions. Its molecular weight of 356.50 g/mol and melting point of 165-170°C reflect its moderate volatility. The acetate group enhances its solubility in organic solvents, facilitating reactions in synthetic processes. Key chemical properties include sensitivity to light and oxidation, necessitating inert storage environments. Its IR and NMR spectra are used for quality verification, with HPLC ensuring purity levels ≥98% for pharmaceutical use.
Main Applications
The primary use of Dienolone Acetate is in the synthesis of steroid hormones, including prednisolone, dexamethasone, and progesterone. It is a critical intermediate in the Marker degradation process, which converts plant sterols into pharmacologically active compounds. Beyond pharmaceuticals, it is researched for potential applications in veterinary medicine and agrochemicals. Its versatility in steroid backbone modification makes it invaluable for developing new therapeutic agents.
Safety and Storage
Handling Dienolone Acetate requires precautions due to its potential irritant effects. Use fume hoods and avoid dust formation. Storage must adhere to 2-8°C in airtight containers with desiccants to prevent hydrolysis. Spills should be contained with inert absorbents and disposed of as hazardous waste. Safety Data Sheets (SDS) must be reviewed prior to use, and local regulations for steroid intermediates followed.
B2B Procurement Guide
When procuring Dienolone Acetate, prioritize suppliers with pharmaceutical-grade certifications (e.g., GMP, US FDA). Confirm batch-specific COA (Certificate of Analysis) for purity, residual solvents, and heavy metals. Bulk pricing is volume-dependent, with contracts often requiring 4-8 weeks for production and QC. Consider logistics for temperature-controlled shipping to maintain stability. Alternative suppliers in China and India dominate the market, but audit their facilities for compliance.
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