Overview
Diclofenac is a widely used nonsteroidal anti-inflammatory drug (NSAID) known for its potent analgesic and anti-inflammatory properties. It is commonly prescribed to manage pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Diclofenac works by inhibiting cyclooxygenase (COX) enzymes, which are responsible for prostaglandin production, thereby reducing inflammation and pain. As a B2B chemical, diclofenac is primarily supplied in bulk to pharmaceutical manufacturers for formulation into tablets, gels, and injectables. Its efficacy and relatively low cost make it a staple in both prescription and over-the-counter medications worldwide.
Physical and Chemical Properties
Diclofenac appears as a white or slightly yellow crystalline powder with a molecular weight of 296.15 g/mol. It has a melting point of 156-158°C and is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. The compound is stable under recommended storage conditions but should be protected from light and moisture to prevent degradation. Its chemical structure includes a phenylacetic acid moiety and two chlorine atoms, contributing to its anti-inflammatory activity. The presence of these functional groups also influences its solubility and stability, which are critical factors in pharmaceutical formulation.
Main Applications
Diclofenac is predominantly used in the pharmaceutical industry for its anti-inflammatory and pain-relieving effects. It is formulated into oral tablets, topical gels, and injectable solutions to treat a variety of conditions, including musculoskeletal disorders, postoperative pain, and acute gout. Topical formulations are particularly popular for localized pain relief, minimizing systemic side effects. Beyond human medicine, diclofenac has veterinary applications, though its use in animals like vultures has raised ecological concerns due to toxicity. In B2B markets, bulk diclofenac is procured by drug manufacturers for generic and branded medications, catering to global demand for affordable pain management solutions.
Safety and Storage
Diclofenac requires careful handling to avoid health risks such as gastrointestinal irritation or allergic reactions. Workers should use gloves and masks to prevent skin contact or inhalation. The compound should be stored in a cool, dry environment, sealed in airtight containers to protect it from humidity and light, which can degrade its quality. Regulatory compliance is essential, particularly for pharmaceutical-grade diclofenac. Buyers must ensure suppliers adhere to Good Manufacturing Practices (GMP) and provide certificates of analysis (CoA) to verify purity and potency. Proper disposal methods should also be followed to minimize environmental impact.
B2B Procurement Guide
When procuring diclofenac in bulk, prioritize suppliers with a proven track record in pharmaceutical raw materials. Key considerations include purity (typically 98-99.5%), compliance with USP, EP, or BP standards, and scalable production capacity. Request samples for in-house testing before large-scale purchases to ensure consistency. Pricing varies based on order volume and purity, with discounts often available for long-term contracts. Logistics should account for temperature-sensitive shipping if required. Partnering with certified suppliers reduces risks of counterfeit or substandard products, ensuring reliable supply chains for pharmaceutical production.
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