Overview
Diclazuril is a synthetic triazine derivative primarily used as an anticoccidial agent in veterinary medicine. It is highly effective against various Eimeria species, which cause coccidiosis in poultry and livestock. Developed as a safer alternative to older coccidiostats, diclazuril is valued for its broad-spectrum activity and minimal side effects. Due to its stability in feed and low toxicity, diclazuril is commonly incorporated into poultry and livestock diets as a preventive measure. Its mode of action involves disrupting the mitochondrial function of coccidia, effectively inhibiting their growth and replication.
Physical and Chemical Properties
Diclazuril appears as a white to off-white crystalline powder with a high melting point, typically around 250°C, where it begins to decompose. It is practically insoluble in water but dissolves well in organic solvents like DMSO and DMF, making it suitable for formulation in medicated feeds or solutions. The compound's molecular structure includes a triazine core, which contributes to its stability and efficacy. Its low solubility in water reduces the risk of environmental contamination, while its stability ensures prolonged activity in animal feed.
Main Applications
Diclazuril is predominantly used in the poultry industry to prevent and treat coccidiosis, a parasitic disease that can cause significant economic losses. It is administered via feed at low concentrations (1-2 ppm) for prophylaxis or higher doses for therapeutic purposes. Livestock such as cattle and sheep also benefit from diclazuril to control coccidial infections. Beyond agriculture, diclazuril is occasionally used in companion animal medicine, particularly for rabbits and other small mammals prone to coccidiosis. Its efficacy and safety profile make it a preferred choice for integrated parasite management programs.
Safety and Storage
While diclazuril is considered safe for animals, proper handling is essential to avoid occupational exposure. Workers should wear gloves, masks, and protective clothing to prevent inhalation or skin contact. The compound is not classified as highly toxic but may cause irritation upon direct exposure. Storage recommendations include keeping diclazuril in a cool, dry environment away from light and moisture to maintain its stability. Containers should be tightly sealed to prevent contamination or degradation. Disposal must comply with local regulations for veterinary pharmaceuticals.
B2B Procurement Guide
When sourcing diclazuril, B2B buyers should prioritize suppliers with veterinary-grade certification and documented quality control processes. Key procurement considerations include verifying the CAS number (101831-37-2) and purity (typically ≥98%). Bulk purchases may offer cost advantages, but buyers should confirm storage capabilities to preserve product integrity. Market prices fluctuate based on raw material availability and demand, but a reference range of $100-$200 per kilogram is common. Buyers are advised to request certificates of analysis (CoA) and ensure compliance with regional regulations for veterinary drug use.
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