Overview
Dichlorophenylphosphine is a key organophosphorus compound with the formula C6H5PCl2. As a reactive intermediate, it serves as a building block for numerous phosphorus-containing compounds. The substance was first synthesized in the early 20th century and has since become indispensable in specialty chemical manufacturing. The compound's commercial importance stems from its dual functionality - the phenyl group provides aromatic stability while the P-Cl bonds offer reactivity for further transformations. Industrial production typically involves the reaction of phosphorus trichloride with benzene derivatives under controlled conditions.
Physical and Chemical Properties
Dichlorophenylphosphine presents as a mobile liquid with a pungent odor, typically ranging from colorless to pale yellow. Its density of 1.31 g/cm³ makes it heavier than water, with which it reacts exothermically. The compound shows good solubility in common organic solvents like toluene and ether but decomposes in protic solvents. Chemically, it behaves as a strong reducing agent and demonstrates significant moisture sensitivity. The phosphorus center exhibits nucleophilic character, making it valuable for forming P-C and P-O bonds. Thermal stability allows handling up to 200°C, though prolonged exposure to air leads to oxidation.
Main Applications
The primary use of dichlorophenylphosphine lies in synthesizing phosphorus ligands for homogeneous catalysis, particularly in pharmaceutical manufacturing. These ligands enable crucial cross-coupling reactions in drug synthesis. The compound also serves as a precursor for flame retardants used in electronics and construction materials. In agrochemical production, it's transformed into organophosphate pesticides and herbicides. Recent developments explore its potential in battery electrolyte additives and photoresist materials for semiconductor fabrication. Approximately 60% of global production supplies the pharmaceutical sector.
Safety and Storage
Dichlorophenylphosphine requires careful handling due to its corrosive nature and water reactivity. Personal protective equipment including acid-resistant gloves, face shields, and vapor respirators are mandatory. Storage demands anhydrous conditions in sealed containers under nitrogen blanket, preferably in corrosion-resistant cabinets. Spills should be contained with inert absorbents and neutralized with sodium bicarbonate. The compound hydrolyzes to release hydrochloric acid, requiring secondary containment in storage areas. Facilities should maintain calcium oxide or other suitable drying agents nearby for emergency moisture control.
B2B Procurement Guide
Industrial buyers should verify supplier certifications for handling reactive phosphorus compounds. Key purchasing criteria include minimum 98% purity (GC), moisture content below 0.1%, and proper inert gas packaging. Preferred shipment methods include UN-approved containers with pressure relief valves. Technical specifications should detail residual solvents, typically requiring benzene content below 50 ppm. Consider suppliers offering just-in-time delivery to minimize storage duration. For reference, container sizes range from 1kg ampoules to 200kg drums, with bulk discounts available above 500kg orders.
Related Manufacturers
- 主营：6-二羟基吲哚、磷钼酸、艾拉莫德中间体、甲基丙二酸、光引发剂、苯芴醇、溴芬酸钠中间体、樟脑醌、钼酸钾、丝素蛋白、盐酸胍、β-丙氨酸甲酯盐酸盐、聚二羟基吲哚、7-去氢胆固醇、甘氨胆酸钠盐、半叶素、胆固醇、2-辛基十二醇、蛋白酶K、D-荧光素钾盐、光引发剂LAP、BIS-TRIS、甲基丙烯酸氧杂环丁烷
- 主营：杜仲素、对位酯、丙烯酸酯、二苯基硅二醇、二氧化硫脲、乙基麦芽酚、饲料添加剂、油酸基硬脂酸
- 主营：甘氨酸、水苏糖、阻燃剂、二氯苯基、硫酸锌、硫酸锆、硫酸锂、硫酸锶、硫酸锰、铝酸锌、1680-21-3、牛磺酸、褪黑素、磷酸铁、丙酸铵、苏云金、碳酸镁、麝香酮、肉桂醛、磷酸铝、王浆酸、椰油胺、赖氨酸、增塑剂、浸膏粉、乙氧基
- 主营：6-二羟基吲哚、二羟基吲哚啉氢溴酸、水解角蛋白、苯基周位酸(8-苯胺、7-去氢胆固醇、石胆酸钠盐、熊去氧胆酸钠盐、2-辛基十二醇、2-巯基噻唑啉、2-巯基苯并咪唑、L-丙交酯、半叶素、乙烯利、环丙磺酰胺、苄氧基胺盐酸盐、1-氨基环丙烷羧酸、4-联苯甲醇丙烯酸酯、4-羟乙烯基氧基二苯、咪鲜胺、可比落、乙交酯、D(+)-丙交酯
- 主营：5-溴-7-氮杂吲哚、柠檬酸钠、液体溴化钙
- 主营：小分子现货、科研小分子、单抗、苯基丙基、多肽、RAS抑制剂、中间体、医药中间体、实验室用试剂、实验小分子、氯苯甲酸、咪唑乙醇、氧代丙腈、贝达喹啉、贝伐单抗、谷氨酰胺、喹啉-21氢、决明内酯、溴喹唑啉、乙基己基
- 主营：[]
- 主营：[]
- 主营：α-氨基、联吡啶、丁烯酸、异丁酮、氟苯基、阻燃剂、10-蒽二、二苯胺、胶黏剂、氨基芴、二苯胍、十八酸、乙二酸、肉桂醇、王浆酸、溴化鏻、乙氧基、豆甾醇、碘乙烷、二乙醇、稀释剂、羟乙基、3382-63-6、氯甲酚、桂皮醇
- 主营：聚乙烯胺、化学试剂、分析试剂、二氯苯基异硫氰酸酯、通用试剂、生化试剂
- 主营：硫酰胺、抗氧剂、中间体、氟苯基、异丁酰胺、l-苯基乳酸、d-苯基乳酸、2-戊酮酸、溴咪唑并、焦谷氨醇、利伐沙班、l-脯氨酰胺、l-氨基丙醇、2-甲基丁酸、2-甲基丁酯、3-氨基丙醇、2-氰基嘧啶、对氰基苯酚、邻氟苯甲酸、邻溴苯乙酸、间溴苯甲酸、丁位癸内酯
- 主营：叔丁醇锂、甲醇锂、氨基锂、二氯苯基异氰酸酯、正丁基锂、氯化锂
- 主营：化学试剂
- 主营：溴苯腈、乙基己酸锌、荧光增白剂、二氯苯基异硫代氰酸酯、羟乙基纤维素、乙酰乙酸乙酯
- 主营：甘氨酸、阻燃剂、胶黏剂、蒽甲酸、退除剂、中性红、3282-24-4、肉桂醛、退镍液、乙氧基、增弹剂、环氧胶、2768-02-7、阻燃毯、7377-08-4、4865-84-3、亮氨酸、抛光盐、5471-63-6、甲基橙、戊二酸、4355-11-7、插入管、防水剂、成核剂