Overview
Dextromethorphan Phosphate is the phosphate salt form of dextromethorphan, a widely used antitussive (cough suppressant) in pharmaceutical formulations. It is particularly valued for its effectiveness in suppressing cough reflexes without the addictive properties associated with opioid-based cough suppressants. The compound is synthesized through the phosphorylation of dextromethorphan, enhancing its solubility and bioavailability. It is commonly incorporated into cough syrups, lozenges, and other over-the-counter cold medications.
Physical and Chemical Properties
Dextromethorphan Phosphate appears as a white to off-white crystalline powder with a molecular weight of 367.38 g/mol. It is soluble in water, making it suitable for liquid formulations, and slightly soluble in ethanol. The compound decomposes at temperatures around 110-115°C. Its stability under recommended storage conditions ensures a long shelf life when kept in a cool, dry environment away from light and moisture. The phosphate group in the molecule enhances its solubility compared to the free base form of dextromethorphan.
Main Applications
The primary application of Dextromethorphan Phosphate is in the pharmaceutical industry, where it serves as a key ingredient in cough suppressants. It is commonly found in over-the-counter cold and flu medications, often combined with other active ingredients like antihistamines or decongestants. Beyond its use in cough syrups, it is also formulated into tablets, lozenges, and extended-release capsules. Its non-opioid nature makes it a preferred choice for pediatric and adult formulations alike, reducing the risk of dependency.
Safety and Storage
Dextromethorphan Phosphate should be handled with care to avoid inhalation of dust or direct contact with skin and eyes. Personal protective equipment, including gloves and safety goggles, is recommended during handling. Storage conditions should be cool, dry, and away from direct light to maintain stability. Bulk quantities should be stored in tightly sealed containers to prevent moisture absorption. In case of accidental exposure, rinse affected areas thoroughly with water and seek medical advice if irritation persists.
B2B Procurement Guide
When procuring Dextromethorphan Phosphate, B2B buyers should prioritize suppliers who provide detailed certificates of analysis (COA) to verify purity and compliance with pharmaceutical standards. The reference price ranges between $50 and $100 per kilogram, depending on purity and order volume. Buyers should also assess the supplier's ability to meet regulatory requirements, such as Good Manufacturing Practices (GMP). Large-scale procurement may benefit from establishing long-term contracts to ensure consistent quality and supply chain reliability.
Related Manufacturers
- 主营：对照品、标准品、当归酸酐、二甲啡烷磷酸盐、佛手柑内酯、新当归内酯、补骨脂甲素、补骨脂乙素、羟基芍药苷、阿魏酸松柏酯、水合氧化前胡素、豆甾醇葡萄糖苷
- 主营：定量勺、硫酸铵、硫酸银、锗试剂、层析柱、大豆油、指示剂、枪状镊、软脂酸、甲基红、开口器、角鲨烯、玫瑰红、进样针、高硼硅、丙烯酸、乙酸铜、甲酸铵、乳酸钙、乙酸钾、氧化锌、乙醛酸、硫酸锌、四甲基、丙二醇
- 主营：砷酸锂、白云石、水合物、六氟磷酸盐、氮化锌、144205-68-5、二叔丁基、利多卡因、碳化钨钴、泛影葡胺、化合物库、1093222-27-5、羟基苯基、八钼酸铵、生化试剂、苯甲酸乙酯、熊去氧胆酸、胆酸二水合、乙酰丙酮锌、湿法云母粉、干法云母粉、苯碳酸甲酯、脱氧胆酸二水、氨基二琥珀酸、对乙酰氨基苯酚
- 主营：联吡啶、甘氨酰、丁烯酸、二甲啡烷磷酸盐36304、阻燃剂、酸性橙、西瓜酮、硫酸锰、氯丁烷、甲醇钙、聚合物、肌氨酸、咯喹酮、烷硫酮、磷酸铵、锑酸钠、双噻吩、磷酸铁、中性红、碳酸镍、磷酸铜、异丁酯、氨丁基、浅铬黄、八(6-溴
- 主营：甘氨酸、甘氨酰、苯硫醚、二甲啡烷磷酸盐、阻燃剂、月桂胺、酸性橙、去铁酮、豆油酸、二苯胺、西瓜酮、八乙基、硫酸锆、磺化钯、二氰基、硫酸锶、硫酸锰、二苯胍、铝酸锶、聚合物、肌氨酸、四氢萘、磷酸铵、甲乙基、甲基亚、碳酸镁
- 主营：苯肼、氯甲基苯乙烯、无水氯化锂、丙酰乙酸甲酯、邻硝基苯磺酰氯、碘甲烷、亚磷酸三苯酯、4-二氢吡喃、苯并噻唑、苄胺、4-溴靛红、苯基锂、叔丁醇钾、三丁基膦、四羟基二硼