Overview
Deoxyribose is a five-carbon sugar (pentose) that is a fundamental component of DNA (deoxyribonucleic acid). It differs from ribose by the absence of one oxygen atom at the 2' position, making it more stable and suitable for long-term genetic information storage. Discovered in the early 20th century, deoxyribose is synthesized in living organisms as part of nucleotide formation. In B2B contexts, deoxyribose is primarily supplied to research institutions, pharmaceutical companies, and biotechnology firms. Its high purity and consistent quality are critical for applications such as DNA sequencing, PCR (polymerase chain reaction), and drug development.
Physical and Chemical Properties
Deoxyribose appears as a white crystalline powder with a melting point of 88-92°C. It is highly soluble in water and slightly soluble in ethanol. The absence of the 2' hydroxyl group in its structure reduces its reactivity compared to ribose, contributing to the stability of DNA. The sugar’s molecular weight is 134.13 g/mol, and its chemical formula is C5H10O4. It is stable under normal storage conditions but may degrade if exposed to excessive heat, light, or moisture. Proper handling and storage are essential to maintain its integrity for laboratory and industrial use.
Main Applications
Deoxyribose is indispensable in molecular biology and genetics. It serves as the backbone of DNA, enabling the storage and transmission of genetic information. In research, it is used to synthesize oligonucleotides, probes, and primers for DNA amplification and sequencing. The pharmaceutical industry employs deoxyribose in the development of antiviral and anticancer drugs. Its derivatives are also explored for potential therapeutic applications, such as gene therapy and diagnostics. Additionally, it finds niche uses in biochemical assays and educational kits.
Safety and Storage
Deoxyribose is generally non-toxic but should be handled with standard laboratory precautions to avoid contamination. Use personal protective equipment (PPE) such as gloves and goggles when working with the compound. Store deoxyribose in a tightly sealed container in a cool, dry place, away from direct sunlight and moisture. Prolonged exposure to humid conditions may lead to clumping or degradation. For long-term storage, consider desiccants or inert atmospheres to preserve purity.
B2B Procurement Guide
When procuring deoxyribose, prioritize suppliers with certifications (e.g., ISO, GMP) and transparent quality control processes. Request certificates of analysis (CoA) to verify purity (typically ≥98%) and absence of contaminants. Bulk purchases may offer cost advantages, but ensure proper storage capacity to prevent waste. Compare prices from multiple vendors, but avoid compromising quality for lower costs. Lead times can vary, so plan orders in advance, especially for high-purity or custom formulations.
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