Overview
Deoxyshikonin is a bioactive naphthoquinone compound extracted from the roots of Lithospermum erythrorhizon, a plant used in traditional Chinese medicine. It is known for its vibrant reddish-brown color and significant pharmacological properties. The compound has garnered attention for its potential therapeutic applications, particularly in treating infections, inflammation, and certain cancers. Research indicates that deoxyshikonin interacts with various cellular pathways, making it a promising candidate for drug development. Its natural origin and multifaceted bioactivity contribute to its growing popularity in both pharmaceutical and cosmetic industries.
Physical and Chemical Properties
Deoxyshikonin is characterized by its reddish-brown crystalline form and a molecular weight of 272.30 g/mol. It has a melting point of approximately 145-147°C and is soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO), though it exhibits poor solubility in water. These properties make it suitable for formulation in alcohol-based solutions or lipid carriers. The compound's stability is influenced by environmental factors like light and moisture, necessitating proper storage conditions. Its chemical structure includes a naphthoquinone core, which is responsible for its redox activity and interaction with biological targets.
Main Applications
Deoxyshikonin is primarily utilized in the pharmaceutical industry for its antibacterial and anti-inflammatory effects. It is being investigated for its potential to inhibit tumor growth and enhance the efficacy of chemotherapy drugs. In cosmetics, it is valued for its antioxidant properties, which help protect skin from oxidative stress and aging. Traditional medicine systems, particularly in East Asia, have long employed deoxyshikonin-rich extracts for wound healing and treating skin disorders. Modern research continues to explore its applications in dermatology, oncology, and infectious disease management.
Safety and Storage
Deoxyshikonin should be handled with caution due to its bioactive nature. Direct contact with skin or eyes may cause irritation, and inhalation of powder should be avoided. Proper personal protective equipment (PPE), such as gloves and masks, is recommended during handling. Storage requires a cool, dry environment, protected from light and moisture to maintain stability. Sealed containers with desiccants are advisable to prolong shelf life. Disposal should comply with local regulations for chemical waste.
B2B Procurement Guide
When procuring deoxyshikonin, buyers should prioritize suppliers who provide certificates of analysis (CoA) detailing purity, CAS number verification, and absence of contaminants. Bulk purchases may offer cost advantages, but quality should not be compromised. It is advisable to source from manufacturers with Good Manufacturing Practice (GMP) certification or those compliant with international regulatory standards. Pricing varies based on purity (typically 95%-98%) and order volume, with reference ranges between $100-$500 per gram.
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