Overview
Demethoxykanugin Standard is a purified flavonoid compound primarily used as an analytical reference material in pharmaceutical and nutraceutical industries. As a derivative of citrus peel constituents, it serves as a critical marker compound for quality assessment of herbal medicines containing similar flavonoids. The standard enables accurate quantification through chromatographic methods like HPLC and LC-MS, ensuring batch-to-batch consistency in botanical extracts. In B2B contexts, this standard is typically supplied by specialized chemical manufacturers with ISO-certified laboratories. The material undergoes rigorous purity verification through multiple analytical techniques including NMR, mass spectrometry, and chromatographic separation. Pharmaceutical companies and research institutions constitute the primary buyers for this reference material.
Physical and Chemical Properties
Demethoxykanugin exhibits characteristic yellow coloration due to its conjugated flavonoid structure, with maximum UV absorption around 270-280 nm. The crystalline powder shows moderate stability under standard laboratory conditions but may degrade upon prolonged exposure to light or humidity. Its melting point range of 210-215°C confirms sample purity during quality checks. The compound's limited water solubility necessitates organic solvents for laboratory preparation, typically methanol or dimethyl sulfoxide (DMSO). In solution, it demonstrates predictable fluorescence properties that facilitate detection in analytical systems. The molecular weight of 298.29 g/mol allows for precise mass spectrometric identification when used as a reference standard.
Main Applications
The primary application of Demethoxykanugin Standard lies in chromatographic method development and validation for flavonoid analysis. Pharmaceutical quality control laboratories use it to establish calibration curves for quantifying analogous compounds in citrus-derived herbal products. Research institutions employ the standard in bioavailability studies of dietary flavonoids. In botanical drug development, this reference material helps standardize extraction processes and verify compound retention during formulation. Some analytical laboratories incorporate it into their system suitability tests for HPLC columns separating oxygenated flavonoids. The standard's consistent performance characteristics make it valuable for inter-laboratory method harmonization in regulatory submissions.
Safety and Storage
While Demethoxykanugin Standard presents low acute toxicity, standard laboratory precautions should be followed. Personal protective equipment including gloves and safety glasses is recommended when handling the powder. The material safety data sheet (MSDS) should be consulted for specific handling procedures. Proper storage requires protection from moisture and light in sealed containers with desiccant packs. Refrigeration at 2-8°C maintains long-term stability, with vials being allowed to reach room temperature before opening to prevent condensation. Shelf life typically exceeds two years when stored correctly, though users should verify stability through periodic re-testing for critical applications.
B2B Procurement Guide
When sourcing Demethoxykanugin Standard, buyers should prioritize suppliers providing comprehensive analytical documentation. Essential documents include a certificate of analysis specifying purity (ideally ≥98%), batch-specific HPLC chromatogram, and residual solvent reports. Reputable suppliers will offer technical support for method development using the standard. Purchasers should confirm the standard's suitability for their intended analytical techniques, particularly regarding detection wavelengths and mobile phase compatibility. Bulk buyers may negotiate pricing for larger quantities, though stability considerations often make smaller, more frequent purchases preferable. Lead times for specialty standards can vary from 2-8 weeks depending on supplier inventory and testing requirements.
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