Overview
Dehydrotanshinone is a lipophilic diterpene quinone extracted from Salvia miltiorrhiza (Danshen), a traditional Chinese medicinal herb. It belongs to the tanshinone family, known for its bioactive properties. The compound has garnered attention for its potential in treating cardiovascular diseases, cancer, and inflammatory conditions due to its multi-target mechanisms. Research highlights its role in modulating oxidative stress and apoptosis pathways, making it a candidate for drug development. Its natural origin and low toxicity profile further enhance its appeal in both pharmaceutical and nutraceutical industries.
Physical and Chemical Properties
Dehydrotanshinone is characterized by its reddish-brown crystalline form and stability under controlled conditions. Its molecular structure includes a quinone moiety, contributing to its redox activity. The compound is soluble in polar organic solvents but poorly soluble in water, which influences its formulation in drug delivery systems. Thermal analysis shows a melting point range of 215-218°C, indicating moderate heat stability. Spectroscopic methods (e.g., NMR, MS) are commonly used for identification and purity assessment, ensuring compliance with pharmaceutical standards.
Main Applications
In pharmaceuticals, dehydrotanshinone is investigated for its cardioprotective effects, including anti-arrhythmic and anti-fibrotic actions. It also shows promise in oncology by inhibiting tumor cell proliferation and metastasis, particularly in liver and breast cancers. Nutraceutical applications include dietary supplements targeting oxidative stress-related disorders. Additionally, it serves as a reference standard in analytical laboratories for quality control of Danshen-derived products.
Safety and Storage
Dehydrotanshinone is generally safe when handled properly. Lab safety protocols recommend using gloves and protective eyewear to avoid skin or eye irritation. Storage in amber glass containers under inert conditions (e.g., nitrogen) preserves its stability. While acute toxicity is low, prolonged exposure to high doses may require further evaluation. Regulatory compliance (e.g., USP, EP) should be confirmed for commercial use, especially in drug formulations.
B2B Procurement Guide
B2B buyers should prioritize suppliers with ISO certification and transparent quality control reports. Key procurement criteria include HPLC-determined purity (≥98%), batch-to-batch consistency, and adherence to Good Manufacturing Practices (GMP). Bulk purchases may benefit from negotiated pricing, but sample testing is advised to verify specifications. Logistics should ensure cold-chain transportation if required, minimizing degradation risks.
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