Overview
Dehydrocorydaline is a quaternary isoquinoline alkaloid primarily extracted from Corydalis species, such as Corydalis yanhusuo. It has garnered attention for its diverse pharmacological activities, including anti-inflammatory, neuroprotective, and potential cardiovascular benefits. This compound is a subject of extensive research in both traditional and modern medicine due to its therapeutic potential. In traditional Chinese medicine, Corydalis plants have been used for centuries to alleviate pain and improve blood circulation. Dehydrocorydaline, as one of the active constituents, contributes to these effects. Its molecular structure and bioactive properties make it a valuable compound for pharmaceutical and research applications.
Physical and Chemical Properties
Dehydrocorydaline is a yellow crystalline powder with a molecular weight of 351.40 g/mol. It has a melting point range of approximately 180-185°C, indicating moderate thermal stability. The compound is soluble in organic solvents like methanol, ethanol, and DMSO but exhibits poor solubility in water, which influences its formulation in pharmaceutical applications. The alkaloid's stability is maintained under recommended storage conditions, which include protection from light and moisture. Its chemical structure, featuring a quaternary nitrogen, contributes to its bioactivity and interaction with biological targets. These properties are critical for researchers and manufacturers when handling and utilizing the compound.
Main Applications
Dehydrocorydaline is primarily utilized in pharmaceutical research and development. Its anti-inflammatory properties make it a candidate for treating conditions like arthritis and other inflammatory disorders. Additionally, its neuroprotective effects are being explored for potential applications in neurodegenerative diseases such as Alzheimer's and Parkinson's. In traditional medicine, extracts containing dehydrocorydaline are used for their analgesic and sedative effects. The compound's ability to modulate neurotransmitter activity and reduce oxidative stress further broadens its therapeutic potential. Ongoing studies aim to harness these properties for developing novel drugs and health supplements.
Safety and Storage
Dehydrocorydaline should be handled with caution to avoid inhalation or direct skin contact. Personal protective equipment, including gloves and lab coats, is recommended during handling. The compound is stable under normal conditions but should be stored in a cool, dry place, away from light and moisture to prevent degradation. Safety data indicates that while dehydrocorydaline is not highly toxic, prolonged exposure or ingestion should be avoided. Proper disposal methods should be followed to minimize environmental impact. Researchers and manufacturers must adhere to safety protocols to ensure safe usage and storage.
B2B Procurement Guide
When procuring dehydrocorydaline, it is essential to verify the purity and quality of the compound. Suppliers should provide certificates of analysis (CoA) confirming purity levels, typically ≥98%. Reputable suppliers with a track record in pharmaceutical-grade alkaloids are preferred to ensure consistency and reliability. Bulk procurement may offer cost advantages, but buyers should assess storage capabilities to maintain compound integrity. Pricing varies based on purity and quantity, with reference prices ranging from $50-$200 per gram. Establishing long-term relationships with trusted suppliers can facilitate smoother transactions and better terms.
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