Deacetylforskolin

Updated: 2026-07-31

Overview

Deacetylforskolin is a diterpene compound naturally found in the roots of Coleus forskohlii, a plant native to Southeast Asia. It is structurally related to forskolin, a well-known bioactive compound, but lacks an acetyl group. This modification can influence its biological activity and solubility. Deacetylforskolin is primarily used in research and supplement formulations due to its potential to support metabolic and cardiovascular health. In recent years, interest in deacetylforskolin has grown, particularly in the nutraceutical and pharmaceutical industries. Its ability to modulate enzyme activity and cellular signaling pathways makes it a subject of ongoing scientific investigation. While not as extensively studied as forskolin, it offers unique properties that may be advantageous for specific applications.

Physical and Chemical Properties

Deacetylforskolin is a white to off-white crystalline powder with a molecular weight of 394.51 g/mol. Its molecular formula is C22H34O6, indicating a complex diterpene structure. The compound is soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO) but has limited solubility in water, which can affect its formulation in aqueous-based products. Key chemical properties include its stability under controlled storage conditions, though it may degrade when exposed to light, heat, or moisture. The absence of an acetyl group compared to forskolin may alter its pharmacokinetics, such as absorption and metabolism. These properties are critical for researchers and manufacturers when designing experiments or products involving deacetylforskolin.

Main Applications

Deacetylforskolin is primarily utilized in pharmaceutical research and dietary supplements. In research settings, it is studied for its potential to activate adenylate cyclase, an enzyme involved in cellular signaling pathways. This activity may have implications for metabolic disorders, cardiovascular health, and other physiological processes. In the dietary supplement industry, deacetylforskolin is often included in formulations aimed at supporting weight management and metabolic function. Its potential to influence fat metabolism and energy expenditure makes it a popular ingredient in niche health products. However, clinical evidence supporting these benefits is still emerging, and further studies are needed to validate its efficacy.

Safety and Storage

Deacetylforskolin should be handled with care to avoid inhalation or skin contact. Personal protective equipment, such as gloves and masks, is recommended when working with the compound in powdered form. Storage conditions are critical to maintaining its stability; it should be kept in a cool, dry place, protected from light and moisture. While generally considered safe for research and supplement use, deacetylforskolin's safety profile in humans is not as well-documented as that of forskolin. Potential side effects or interactions with medications are not fully understood, so caution is advised, especially in vulnerable populations. Always consult safety data sheets and regulatory guidelines before use.

B2B Procurement Guide

When procuring deacetylforskolin for business purposes, it is essential to verify the supplier's credentials and product purity. Reputable suppliers should provide certificates of analysis (CoA) detailing the compound's purity, typically ranging from 95% to 98% for research-grade material. Bulk purchases may offer cost advantages, but quality should not be compromised. Price ranges vary depending on purity and quantity, with reference prices approximately $50-$200 per gram. Consider testing samples before large-scale procurement to ensure consistency and quality. Additionally, compliance with local regulations for import and use should be confirmed, especially for pharmaceutical or supplement applications.