Overview
Darunavir is a potent antiretroviral drug developed for the treatment of HIV-1 infection. It is classified as a protease inhibitor, which works by blocking the activity of the HIV protease enzyme, thereby preventing the virus from replicating. Darunavir is typically administered in combination with other antiretroviral agents, such as ritonavir, to enhance its bioavailability and efficacy. Since its approval by the FDA in 2006, darunavir has become a cornerstone in the management of HIV/AIDS, particularly for treatment-experienced patients with resistant strains. It is marketed under the brand name Prezista and is available in both tablet and oral suspension forms.
Physical and Chemical Properties
Darunavir is a white to off-white crystalline powder with a molecular weight of 547.67 g/mol. Its molecular formula is C27H37N3O7S, and it has a melting point of approximately 100-105°C. The compound is soluble in organic solvents like ethanol and methanol but has limited solubility in water. Darunavir is stable under recommended storage conditions but should be protected from light and moisture to maintain its potency. Its chemical structure includes a sulfonamide group, which contributes to its high binding affinity for the HIV protease enzyme.
Main Applications
Darunavir is primarily used in the treatment of HIV-1 infection, particularly in cases where the virus has developed resistance to other protease inhibitors. It is often prescribed as part of a combination therapy, known as highly active antiretroviral therapy (HAART), to maximize viral suppression and minimize the risk of resistance. In addition to its use in adults, darunavir is also approved for pediatric patients aged 3 years and older. Its efficacy and safety profile make it a preferred choice for both initial and salvage therapy in HIV management.
Safety and Storage
Darunavir should be handled with care to avoid exposure. Laboratory and pharmaceutical personnel should use gloves, eye protection, and appropriate ventilation when working with the compound. Inhalation or ingestion can pose health risks, and accidental exposure should be addressed immediately with medical attention. For storage, darunavir should be kept in a tightly sealed container at a controlled temperature of 2-8°C. It is sensitive to moisture and light, so desiccants and opaque containers are recommended to maintain stability.
B2B Procurement Guide
When procuring darunavir, B2B buyers should prioritize suppliers with verified credentials and compliance with Good Manufacturing Practices (GMP). Request a Certificate of Analysis (COA) to confirm purity, potency, and absence of contaminants. It is also advisable to assess the supplier’s ability to provide stability data and batch records. Pricing can vary based on quantity, purity, and market demand, so obtaining multiple quotes is recommended. Ensure all transactions adhere to pharmaceutical regulatory requirements.
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