Overview
D-(+)-Threitol is a stereoisomer of erythritol, belonging to the family of sugar alcohols. It is a naturally occurring compound but is often synthesized for industrial applications. Its chiral nature makes it valuable in asymmetric synthesis and pharmaceutical manufacturing. Unlike other sugar alcohols, D-(+)-Threitol exhibits low caloric content and is non-cariogenic, making it suitable for dietary and oral care products. Its stability under various pH conditions further broadens its utility in food and chemical industries.
Physical and Chemical Properties
D-(+)-Threitol is characterized by its white crystalline form and sweet taste, though less sweet than sucrose. It has a melting point of 88-90°C and is highly soluble in water, which facilitates its use in aqueous formulations. The compound is optically active, with a specific rotation of [α]D +14° (c=10, H2O). Its non-hygroscopic nature ensures stability during storage and handling, distinguishing it from other polyols that may absorb moisture.
Main Applications
In the pharmaceutical industry, D-(+)-Threitol serves as a chiral building block for drug synthesis, particularly in antiviral and anticancer agents. Its ability to form stable complexes with metal ions is exploited in catalysis and material science. The food industry utilizes it as a low-calorie sweetener and humectant. Its compatibility with other ingredients and mild flavor profile make it ideal for sugar-free confectionery and baked goods. Additionally, it is used in cosmetic formulations for its moisturizing properties.
Safety and Storage
D-(+)-Threitol is classified as GRAS by regulatory authorities, ensuring its safety in food and pharmaceutical applications. However, standard laboratory precautions, such as wearing gloves and goggles, are recommended during handling. Storage should be in tightly sealed containers under ambient conditions. Prolonged exposure to high humidity or temperatures above 40°C should be avoided to prevent clumping or degradation.
B2B Procurement Guide
When procuring D-(+)-Threitol, prioritize suppliers with certifications like ISO or GMP to ensure quality and consistency. Request certificates of analysis (CoA) to verify purity, which typically ranges from 98% to 99.5% for industrial-grade material. Bulk buyers should negotiate pricing based on volume, as economies of scale apply. Consider logistical factors such as lead times and packaging options (e.g., 25 kg bags or custom sizes) to align with production schedules.
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