Overview
D-Methionine is the D-isomer of the essential amino acid methionine, characterized by its sulfur-containing side chain. Unlike its L-isomer, D-Methionine is less common in nature but plays a specialized role in biochemical and industrial applications. It is synthesized for use in pharmaceuticals, where it serves as a chiral building block, and in animal nutrition to balance amino acid profiles. Methionine is critical for metabolic processes, including methylation and antioxidant defense. The D-form is often used in racemization studies or as a supplement in specific formulations where its stereochemistry is advantageous. Its industrial production typically involves chemical synthesis or enzymatic resolution.
Physical and Chemical Properties
D-Methionine appears as a white crystalline powder with a molecular weight of 149.21 g/mol. It has a melting point of 280-282°C (with decomposition) and a density of 1.34 g/cm³. The compound is soluble in water and dilute acids but only slightly soluble in ethanol, making it suitable for aqueous formulations. Its sulfur-containing structure contributes to its role in forming disulfide bonds in proteins and participating in transmethylation reactions. The D-isomer exhibits optical activity, rotating plane-polarized light in the opposite direction compared to L-Methionine. Stability is maintained under dry, cool storage conditions, though prolonged exposure to moisture or heat may degrade the compound.
Main Applications
In pharmaceuticals, D-Methionine is used as an intermediate in drug synthesis, particularly for chiral compounds. It is also studied for its potential neuroprotective effects and role in detoxification pathways. The animal feed industry incorporates it to optimize amino acid balance, especially in poultry and swine nutrition, where it supports growth and feathering. Food supplements may include D-Methionine for its purported antioxidant benefits, though L-Methionine is more common in human nutrition. Research laboratories utilize it for studying enzyme specificity and metabolic pathways. Industrial applications extend to cosmetic formulations, where it aids in protein stabilization.
Safety and Storage
D-Methionine is generally regarded as safe but requires standard handling precautions. Avoid inhalation of dust and direct contact with eyes or skin. Use personal protective equipment (PPE) such as gloves and goggles in laboratory settings. Storage should be in tightly sealed containers, placed in a cool, dry environment away from light and moisture to prevent degradation. Bulk quantities are typically packaged in multi-layered bags or drums with desiccants. Shelf life is typically 2-3 years when stored properly. Dispose of waste according to local regulations for organic compounds.
B2B Procurement Guide
When procuring D-Methionine, prioritize suppliers with certifications like ISO, GMP, or USP to ensure quality. Request certificates of analysis (CoA) confirming purity (≥98%) and absence of heavy metals or residual solvents. Bulk buyers should negotiate pricing tiers for quantities above 100 kg. Consider logistics: the product is non-hazardous but may require climate-controlled shipping in humid regions. Spot-check deliveries for consistency in particle size and color. For pharmaceutical-grade material, validate compliance with pharmacopeial standards (e.g., USP-NF or EP). Long-term contracts with reliable manufacturers can stabilize supply chains and pricing.
Related Manufacturers
- 主营：全氟三丁胺、二苄叉山梨醇、六氟丙烯二聚体、蛋氨酸、六氟环氧丙烷二聚体、异丙醇铝、纳米勃姆石、二异戊基硫醚、隐色结晶紫、邻菲罗啉
- 主营：有机原料、中间体、香精香料、蛋氨酸、催化剂、有机硅、表面活性剂
- 主营：化学试剂、氯金酸、卡尔费休、蛋氨酸、乙醇、异丙醇、药用辅料、依地酸钙钠、碳酸钠、盐酸氨丁三醇、龙胆酸、枸橼酸钠、甲醇、氢氧化钠、钴锰催化剂、硫酸锰、乙腈、色谱试剂、助剂、指示剂、醋酸锰、醋酸钴、氨丁三醇、尿素、硼酸
- 主营：医药中间体、材料中间体、化工原料、蛋氨酸、试剂
- 主营：氯化氢乙醇、二苯基硅二醇、甲基磺酸铋、蛋氨酸、阻燃剂DDP、萃取剂、HTPB、防老剂
- 主营：氯菊酯、转移剂、聚酯树脂、二甲氧基、驱蚊原液、食品香料、缩水甘油酯、蚊香增效剂、丙烯酸缩水、环氧稀释剂、硅烷偶联剂、超疏水材料、对甲氧基苯酚、对羟基苯甲醚、乙烯基双封头、苯基缩水甘油醚
- 主营：化工中间体、有机中间体、香精香料、蛋氨酸、添加剂、表面活性剂、天然/合成树脂、分析试剂、日化原料、催化剂、高分子材料
- 主营：敌草隆、球虫酯、2-己二醇、防黄剂HN-130、靛红酸酐、十一烯酸锌、吲哚原料、4-丁二醇、2-丙二醇、氢化松油醇、羟乙甲纤维素、龙胆紫、二甲基乙烯脲、对叔戊基苯酚、3-二羟基丙酮、乙氧酰胺苯甲酯
- 主营：化学试剂、生物试剂、分析试剂、蛋氨酸、基准试剂、生化试剂
- 主营：肉桂酸钾、敌草隆、苯基周位酸、甲基三氧化铼、五氯硫酚、二醋酸纤维素、吲哚、三醋酸纤维素、溴化亚铜、2-乙基蒽醌、香兰素
- 主营：乙氧羰基、苯并氮杂、氮杂双环、蛋氨酸、亚氨基二、五甲基环、氨基二乙酸、四氟硼酸盐、三叔丁基膦、苄酯盐酸盐、4-异丙基吡啶、溴甲基环戊烷、2-溴-7-羟基萘
- 主营：溶蛋白、胰蛋白酶、玉米醇蛋白、蔗糖、硫代半乳糖苷、TRIS
- 主营：甲硫氨酸、白僵菌素、薯蓣皂苷
- 主营：香芹酚、抗氧化增香剂、DCHP、2-咪唑烷酮、对叔戊基苯酚、柠檬烯、五氯硫酚、愈创木酚、邻硝基苯甲醛、二醋酸纤维素、氢化油、硅烷偶联剂、润滑剂、脱模剂、分散剂、消泡剂、阻燃剂、抗氧剂、增塑剂、附着力促进剂、杀菌剂、增稠剂、乳化剂、防老剂、缓蚀阻垢剂
- 主营：氧化剂、稀释剂、氧化钙、蛋氨酸、氟化钡、甲酸钠、2-甲基萘、对氯苯酚、氢氧化铋、对溴甲苯、高碘酸钠、氟硅酸铵、氢氧化钡、硫氰酸钾、对氯甲苯、二氯甲烷、氟化氢铵、橡胶防老剂、药物中间体、三正丙基胺、多乙烯多胺、电镀添加剂、尼泊金乙酯、邻氨基苯酚、食品保存剂、对甲苯磺酰氯