Overview
D-Cysteine Monohydrate is the D-enantiomer of cysteine, a sulfur-containing amino acid. Unlike its L-form counterpart, it is less common in nature but holds significance in specialized biochemical and pharmaceutical applications. The monohydrate form ensures stability during storage and handling. As a chiral building block, it is valued for its thiol (-SH) group, which participates in redox reactions and metal chelation. Its applications span from drug synthesis to nutritional research, often serving as a precursor or stabilizer in complex formulations.
Physical and Chemical Properties
D-Cysteine Monohydrate crystallizes as a white powder with a faint characteristic odor. Its solubility in water makes it suitable for aqueous formulations, while its stability under inert conditions is critical for industrial use. The compound decomposes upon heating rather than melting clearly, a trait typical of amino acids. Its thiol group is prone to oxidation, necessitating oxygen-free environments or antioxidants like EDTA in solutions. Analytical methods such as HPLC and NMR are commonly used to verify purity and enantiomeric excess.
Main Applications
In pharmaceuticals, D-Cysteine Monohydrate acts as an intermediate for synthesizing chiral drugs, particularly those targeting neurological or metabolic disorders. Its ability to modulate metal ions also finds use in chelation therapy research. The supplement industry employs it in niche products where D-amino acids are required. Additionally, it serves as a reducing agent in biochemical assays and a stabilizer for enzymes sensitive to oxidation. Research into its role in peptide synthesis continues to expand its utility.
Safety and Storage
Due to its reactive thiol group, D-Cysteine Monohydrate requires careful handling to prevent oxidation or degradation. Storage in airtight containers under nitrogen atmosphere is recommended for long-term stability. Personal protective equipment (PPE) such as gloves and goggles is mandatory during handling. Spills should be neutralized with dilute hydrogen peroxide and cleaned promptly. Dispose of waste according to local regulations for sulfur-containing compounds.
B2B Procurement Guide
When sourcing D-Cysteine Monohydrate, prioritize suppliers with documented quality control processes, such as ISO 9001 certification. Batch-specific certificates of analysis (CoA) should confirm purity (≥98%), enantiomeric excess, and absence of heavy metals. Bulk buyers should negotiate pricing based on volume, with prices typically ranging from $50 to $200/kg. Consider lead times and cold-chain logistics if ordering large quantities. Sample testing is advisable to validate consistency before full-scale procurement.
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