Overview
Cyclopropylmethanol is an organic alcohol featuring a cyclopropyl group attached to a hydroxymethyl moiety. It is a key intermediate in the synthesis of pharmaceuticals, including antiviral and antifungal agents, due to its unique three-membered ring structure, which imparts steric and electronic effects. This compound is commercially available in laboratory and industrial quantities, with purity grades ranging from technical (90-95%) to high-purity (≥98%). Its reactivity makes it valuable for constructing complex molecular frameworks in medicinal chemistry and material science.
Physical and Chemical Properties
Cyclopropylmethanol is a low-viscosity liquid with a mild, alcohol-like odor. Its boiling point (120-122°C) and density (0.91 g/cm³) are typical for small cyclic alcohols. The compound’s solubility profile allows it to act as a co-solvent in reactions involving polar and non-polar reagents. Chemically, the cyclopropyl ring is prone to ring-opening reactions under acidic or oxidative conditions, making it a versatile building block. The hydroxyl group participates in standard alcohol reactions (e.g., esterification, oxidation), while the ring strain enhances reactivity in nucleophilic substitutions.
Main Applications
In pharmaceuticals, cyclopropylmethanol is used to synthesize prodrugs and active ingredients, such as cyclopropane-containing antibiotics and protease inhibitors. Its rigid structure enhances binding affinity to biological targets. Agrochemical manufacturers employ it to create herbicides and insecticides with improved stability. Additionally, it serves as a precursor for specialty polymers and fragrances, where its cyclic structure contributes to thermal resistance and scent longevity.
Safety and Storage
Cyclopropylmethanol is flammable (flash point ~32°C) and requires storage in fireproof cabinets. Inhalation or skin contact may cause irritation; NIOSH-approved respirators and nitrile gloves are recommended. Spills should be contained with inert absorbents. For long-term storage, use nitrogen-purged containers to prevent oxidation. Bulk shipments must comply with GHS hazard classifications (H226, H315, H319) and transport regulations (UN 1987, Class 3).
B2B Procurement Guide
When sourcing cyclopropylmethanol, prioritize suppliers with ISO 9001 certification and batch-specific COAs (Certificates of Analysis). Key parameters include purity (HPLC ≥98%), water content (<0.5%), and residual solvents (e.g., <500 ppm). Procurement options range from 1 kg R&D samples to metric-ton bulk orders. Pricing varies by quantity and purity; negotiate contracts with tiered discounts. For international shipments, confirm compliance with REACH, TSCA, and local chemical inventories.
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