Overview
Cyclo(Glycyl-Seryl) is a cyclic dipeptide (diketopiperazine) formed from glycine and serine amino acids. As a simple cyclic peptide, it serves as a model compound in peptide chemistry studies and has attracted interest for its potential biological activities. The cyclic structure provides enhanced stability compared to linear peptides, making it useful in various biochemical applications. This compound is typically synthesized through cyclization of linear dipeptide precursors or via solid-phase peptide synthesis methods. Its small size and well-defined structure make it valuable for studying peptide conformation and interactions in drug discovery research.
Physical and Chemical Properties
Cyclo(Glycyl-Seryl) appears as a white crystalline powder with good stability at room temperature when properly stored. The molecule has a molecular weight of 144.13 g/mol and shows characteristic absorption in the UV spectrum due to its peptide bonds. It demonstrates moderate solubility in water (approximately 10-20 mg/mL at 25°C) but limited solubility in most organic solvents except DMSO and DMF. The cyclic structure confers unique conformational properties compared to linear peptides, including restricted rotation about the peptide bonds and distinct hydrogen bonding patterns. These characteristics influence its reactivity and biological interactions. Thermal analysis typically shows decomposition rather than a clear melting point, beginning around 200-220°C.
Main Applications
In biochemical research, Cyclo(Glycyl-Seryl) serves as a model compound for studying peptide conformation, hydrogen bonding, and molecular recognition processes. Its stable cyclic structure makes it useful for investigating peptide-protein interactions and enzyme-substrate relationships. The pharmaceutical industry utilizes this compound as a building block for more complex peptide synthesis and as a scaffold for drug design. Some studies have explored its potential as a bioactive molecule, though clinical applications remain investigational. Additionally, it finds use in specialty chemical production and as a reference standard in analytical chemistry.
Safety and Storage
While Cyclo(Glycyl-Seryl) is not classified as highly hazardous, standard laboratory precautions should be followed. Personal protective equipment including gloves and safety glasses is recommended when handling. The compound should be stored in tightly sealed containers under cool, dry conditions (2-8°C) to prevent degradation. In case of accidental exposure, affected areas should be flushed with copious water. While no significant toxicity has been reported, material safety data should be consulted for specific handling procedures. Proper ventilation is advised when working with powdered forms to avoid inhalation exposure.
B2B Procurement Guide
When procuring Cyclo(Glycyl-Seryl) for commercial or research purposes, buyers should specify required purity levels (typically 95% minimum for research use, 98%+ for pharmaceutical applications). Certificates of analysis should include HPLC purity data and mass spectrometry confirmation. Suppliers should provide detailed storage and handling recommendations. Minimum order quantities often apply, with pricing varying significantly based on purity and scale (research grams vs. bulk kilograms). Lead times can range from 2-6 weeks for custom synthesis. For GMP-grade material, additional documentation including method validation data is essential.
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