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cyclo(gly-ser)

Updated: 2026-08-04

Overview

Cyclo(glycyl-seryl) is a cyclic dipeptide, also known as a diketopiperazine, formed from glycine and serine amino acids. It is widely used in biochemical and pharmaceutical research due to its structural simplicity and biological relevance. The compound serves as a model for studying peptide interactions and as a building block in peptide synthesis. Cyclo(glycyl-seryl) is particularly valued for its stability and solubility in aqueous solutions, making it suitable for various experimental applications. Its cyclic structure differentiates it from linear peptides, offering unique properties for research and industrial use.

Physical and Chemical Properties

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Cyclo(glycyl-seryl) appears as a white to off-white crystalline powder with a molecular weight of 144.13 g/mol. It is soluble in water and slightly soluble in organic solvents, which facilitates its use in biochemical assays. The compound decomposes at approximately 250-260°C, indicating thermal instability at higher temperatures. The cyclic structure of cyclo(glycyl-seryl) contributes to its stability under normal laboratory conditions. This stability, combined with its solubility profile, makes it a versatile compound for research purposes. However, prolonged exposure to moisture or light should be avoided to maintain its integrity.

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Main Applications

Cyclo(glycyl-seryl) is primarily used in biochemical research as a model compound for studying peptide structures and interactions. Its cyclic nature provides insights into the conformational behavior of peptides, which is valuable for understanding protein folding and stability. In the pharmaceutical industry, cyclo(glycyl-seryl) serves as an intermediate in peptide synthesis. It is also explored for potential bioactive properties, though further research is needed to confirm its therapeutic applications. Additionally, it is used in academic settings for teaching purposes, demonstrating peptide chemistry principles.

Safety and Storage

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Cyclo(glycyl-seryl) should be handled with care to avoid inhalation or direct contact with skin and eyes. Personal protective equipment, such as gloves and lab coats, is recommended when working with this compound. In case of exposure, rinse thoroughly with water and seek medical advice if necessary. Proper storage conditions include keeping the compound in a cool, dry place, protected from light and moisture. Sealed containers are ideal to prevent degradation. Long-term storage at low temperatures (e.g., refrigerated) may further enhance stability, depending on the intended use.

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B2B Procurement Guide

When procuring cyclo(glycyl-seryl) for B2B purposes, it is essential to verify the purity and CAS number (3705-26-8) with the supplier. Request certificates of analysis (CoA) to ensure the product meets your specifications. Prices vary depending on quantity and supplier, so obtaining multiple quotes is advisable. Consider suppliers with a track record of providing high-quality biochemical compounds. Bulk purchases may offer cost advantages, but ensure proper storage facilities are available to maintain product integrity. Additionally, inquire about shipping conditions to prevent exposure to adverse environmental factors during transit.

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