Overview
β-Sitosterol is a phytosterol commonly found in plant cell membranes, structurally similar to cholesterol. It is extracted from vegetable oils like soybean, corn, and rapeseed oil, or from pine tree pulp. Due to its ability to inhibit cholesterol absorption in the intestines, it is widely used in dietary supplements and functional foods. In addition to its cholesterol-lowering effects, β-sitosterol exhibits anti-inflammatory and antioxidant properties, making it valuable in pharmaceuticals and cosmetics. Its safety profile is well-documented, and it is approved for use in various regions, including the U.S. and EU.
Physical and Chemical Properties
β-Sitosterol is a white, crystalline powder with a melting point of 140-142°C. It is insoluble in water but dissolves readily in organic solvents such as ethanol, chloroform, and ether. Its molecular formula is C29H50O, with a molecular weight of 414.71 g/mol. The compound is stable under normal storage conditions but should be protected from light, heat, and moisture to prevent degradation. Its chemical structure includes a steroid nucleus with a hydroxyl group at the 3-position, contributing to its biological activity.
Main Applications
In the pharmaceutical industry, β-sitosterol is used in drugs to lower LDL cholesterol and treat benign prostatic hyperplasia (BPH). It is also a key ingredient in nutraceuticals, such as cholesterol-lowering margarines and dietary supplements. The cosmetics industry utilizes β-sitosterol for its anti-inflammatory and skin-soothing properties, often incorporating it into creams and lotions for sensitive skin. Additionally, it serves as a food additive in fortified products to enhance nutritional value.
Safety and Storage
β-Sitosterol is generally recognized as safe (GRAS) by regulatory authorities, though excessive consumption may lead to minor digestive issues like nausea or diarrhea. It is non-toxic and non-carcinogenic, with no significant side effects reported at recommended doses. For storage, β-sitosterol should be kept in a tightly sealed container in a cool, dry place, away from direct sunlight. Proper handling minimizes oxidation and ensures product stability over time.
B2B Procurement Guide
When procuring β-sitosterol, B2B buyers should prioritize purity (typically 90-99%), verified through certificates of analysis (CoA). Supplier reliability is critical—look for ISO or GMP-certified manufacturers to ensure consistent quality. Price varies based on purity, sourcing (natural vs. synthetic), and order volume. Bulk purchases often qualify for discounts. Additionally, consider logistics, such as packaging (25kg drums or custom sizes) and lead times, to align with production schedules.
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