Overview
Creatinine Standard is a certified reference material (CRM) widely used in clinical diagnostics and research. It serves as a primary standard for calibrating instruments that measure creatinine levels in blood and urine, which are critical for assessing kidney function. The standard is typically supplied with a detailed certificate of analysis (CoA) that includes information about purity, uncertainty, and traceability to international reference materials. High-purity creatinine standards are essential for ensuring accurate and reproducible test results in medical laboratories.
Physical and Chemical Properties
Creatinine Standard is a white crystalline powder with a molecular weight of 113.12 g/mol. It is soluble in water and slightly soluble in ethanol, making it suitable for aqueous-based calibration solutions. The compound is stable under recommended storage conditions but can degrade when exposed to moisture, light, or extreme temperatures. Its melting point is around 300°C, though it may decompose at this temperature rather than melt cleanly.
Main Applications
The primary use of Creatinine Standard is in clinical laboratories for calibrating automated analyzers that measure creatinine levels in patient samples. Accurate creatinine measurement is vital for calculating glomerular filtration rate (GFR), a key indicator of kidney function. In pharmaceutical quality control, creatinine standards are used to validate analytical methods and ensure the accuracy of dissolution testing. Research laboratories also use these standards in studies related to muscle metabolism and renal physiology.
Safety and Storage
While creatinine is a naturally occurring compound in the human body, the concentrated standard form requires careful handling. Laboratory personnel should wear appropriate PPE, including gloves and safety glasses, when working with the powder. Proper storage is critical for maintaining the standard's integrity. It should be kept in its original container, tightly sealed, in a cool (2-8°C), dry environment protected from light. The standard should not be used if discoloration or clumping is observed.
B2B Procurement Guide
When purchasing Creatinine Standard for laboratory use, buyers should prioritize suppliers that provide comprehensive documentation, including certificates of analysis with batch-specific data. Traceability to NIST or other recognized standards is essential for quality assurance. Consider the intended application when selecting purity levels - clinical laboratories typically require ≥98% purity with low endotoxin levels. For pharmaceutical applications, standards meeting USP or EP specifications may be necessary. Bulk purchases should include stability data to ensure the product remains valid throughout its intended use period.
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