Overview
Betulinic Acid Standard is a certified reference material (CRM) primarily used in pharmaceutical and biomedical research. As a pentacyclic triterpenoid isolated from birch bark, it serves as a critical quality control standard for herbal medicine analysis and drug development projects. The compound's standardized form ensures reproducibility in experiments studying its bioactive properties, including selective cytotoxicity against melanoma cells and HIV-1 inhibition. Analytical laboratories require this standard for method validation according to ICH guidelines, particularly in HPLC and LC-MS applications.
Physical and Chemical Properties
Betulinic Acid Standard exhibits characteristic triterpenoid properties with a rigid pentacyclic structure. Its molecular weight of 456.71 g/mol and defined melting point (256-258°C) make it suitable for thermogravimetric analysis calibration. The compound's low water solubility but good organic solvent compatibility dictates its preparation methods for laboratory use. Its UV absorbance at 210 nm allows for sensitive detection in chromatographic systems. The crystalline form ensures stability during transport and storage when proper conditions are maintained.
Main Applications
In pharmaceutical quality control, this standard validates analytical methods for betulinic acid quantification in plant extracts and formulated products. Research laboratories use it as a reference compound in studies exploring its mechanism of action against cancer cell lines. The standard is essential for developing betulinic acid derivatives with enhanced bioavailability. Cosmetic manufacturers employ it to standardize anti-aging formulations containing birch bark extracts. Recent applications include standardization of antiviral herbal preparations in traditional medicine research.
Safety and Storage
Proper handling requires laboratory coats, gloves, and eye protection due to potential irritant effects. Although not classified as acutely toxic, prolonged exposure should be avoided through proper ventilation and containment measures. The standard must be stored in amber vials with PTFE-lined caps at 2-8°C to prevent degradation. Desiccant packets are recommended to maintain stability. For long-term storage beyond six months, aliquoting under inert gas (e.g., argon) extends shelf life. The material shows sensitivity to UV light and oxidation.
B2B Procurement Guide
When sourcing Betulinic Acid Standard, prioritize suppliers providing full analytical documentation including NMR spectra, mass spectrometry data, and chromatographic purity certificates. Batch-specific certificates of analysis are mandatory for regulatory compliance. Consider minimum order quantities (MOQs) and lead times, as high-purity standards often require custom preparation. For bulk procurement (100mg+), request stability data and accelerated degradation studies. Reputable suppliers should offer temperature-controlled shipping with dry ice or cold packs for international deliveries.
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