Overview
Cheilanthifoline Standard is a purified isoquinoline alkaloid reference material primarily sourced from Corydalis species plants. As a certified reference standard, it plays critical roles in phytochemical analysis and quality assurance processes for traditional Chinese medicine preparations. The compound is particularly valued for its use in validating analytical methods through techniques like high-performance liquid chromatography (HPLC) and mass spectrometry. The standard is manufactured under strict quality control protocols to ensure batch-to-batch consistency, with typical purity levels exceeding 98%. Pharmaceutical laboratories and research institutions utilize this standard for both qualitative and quantitative analysis of herbal extracts, contributing to the standardization of plant-based medicines.
Physical and Chemical Properties
Cheilanthifoline presents as a fine crystalline powder with characteristic UV absorption maxima between 280-290 nm, an important feature for spectroscopic identification. Its molecular structure contains both tertiary amine and phenolic functional groups, contributing to moderate polarity that affects chromatographic behavior. The compound demonstrates stability under recommended storage conditions but may degrade when exposed to prolonged heat or strong light. In solution, cheilanthifoline shows optimal stability in slightly acidic to neutral conditions (pH 5-7). Analytical studies typically employ methanol or ethanol as solvents due to the compound's good solubility in these polar organic solvents. The melting point range serves as a key physical parameter for identity confirmation in quality control procedures.
Main Applications
The primary application of cheilanthifoline standard lies in quality control laboratories for authenticating and quantifying this alkaloid in Corydalis extracts. Regulatory bodies and pharmacopoeias require such reference standards for compliance testing of herbal medicines targeting pain relief and sedative effects. Research institutions employ it in pharmacological studies investigating the compound's potential cardiovascular and neurological activities. In botanical extract manufacturing, the standard enables accurate standardization of products to specified alkaloid content levels. Analytical laboratories use it as a system suitability test compound for method validation and equipment calibration. The reference material is particularly valuable for developing and verifying HPLC and LC-MS methods due to its well-characterized chromatographic properties.
Safety and Storage
As a bioactive alkaloid, cheilanthifoline standard requires careful handling with appropriate personal protective equipment including gloves and safety goggles. The material should only be used in well-ventilated areas or fume hoods to prevent inhalation exposure. Spills should be contained immediately using absorbent materials and disposed of as hazardous chemical waste. For long-term stability, the standard must be stored in amber glass vials with PTFE-lined caps at controlled refrigeration temperatures (2-8°C). Desiccants are recommended to prevent moisture absorption. Each container should be clearly labeled with preparation date, concentration, and expiration date (typically 24 months when stored properly). Avoid repeated freeze-thaw cycles of prepared solutions.
B2B Procurement Guide
When sourcing cheilanthifoline standard, buyers should verify supplier credentials including ISO certification and compliance with current Good Manufacturing Practice (cGMP) standards. Essential documentation includes detailed certificates of analysis specifying purity (HPLC area percentage), residual solvents, and heavy metal content. Reputable suppliers provide batch-specific UV/VIS and MS spectra for identity confirmation. For research-grade material, request chromatographic purity ≥98% with documentation of analytical methods. Bulk pharmaceutical buyers should inquire about stability studies and impurity profiles. Consider suppliers offering customized concentrations or solution preparations for specific applications. Lead times for specialty phytochemical standards typically range 2-6 weeks, with express options available at premium pricing.
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