Overview
Corticosterone is a naturally occurring glucocorticoid hormone primarily studied in rodents, where it serves as the dominant corticosteroid (unlike cortisol in humans). It is synthesized in the adrenal cortex's zona fasciculata and plays a central role in the hypothalamic-pituitary-adrenal (HPA) axis. As a key mediator of stress responses, corticosterone regulates metabolism, immune function, and behavior. Its levels fluctuate diurnally and spike during stress. Researchers use synthetic corticosterone to study stress-related disorders, neurobiology, and endocrine disruption in animal models.
Physical and Chemical Properties
Corticosterone is a white crystalline solid with low water solubility but good solubility in organic solvents like ethanol and DMSO. Its molecular structure includes a steroid backbone with hydroxyl groups at positions 11β and 21, critical for biological activity. The hormone is stable when stored properly but degrades under prolonged exposure to light, heat, or humidity. Analytical methods like HPLC and LC-MS are used to verify purity, which typically exceeds 98% for research-grade material. Its melting point (180-182°C) serves as a key identifier in quality control.
Main Applications
In biomedical research, corticosterone is widely used to simulate chronic stress in rodent studies. It helps investigate conditions like depression, anxiety, and metabolic syndrome. Researchers administer it via injection, oral routes, or subcutaneous implants to elevate circulating levels. The compound also serves as a standard in immunoassays (e.g., ELISA) to quantify endogenous corticosterone in blood, saliva, or brain tissue. Pharmaceutical studies utilize it as a reference material when developing glucocorticoid receptor modulators or studying adrenal function.
Safety and Storage
As a bioactive steroid, corticosterone requires careful handling. Lab personnel should wear gloves, goggles, and protective clothing to prevent skin absorption or accidental ingestion. Though not classified as highly toxic, prolonged exposure may disrupt endocrine function. For long-term storage, aliquots should be kept at -20°C in amber vials with desiccants. Solutions prepared in ethanol or DMSO remain stable for weeks at -20°C but should avoid freeze-thaw cycles. Contamination risks are minimized by using sterile techniques during weighing and solution preparation.
B2B Procurement Guide
When sourcing corticosterone for research, prioritize suppliers with ISO 9001 certification or GMP compliance for reagents. Key specifications include HPLC purity (≥98%), low endotoxin levels, and detailed certificates of analysis (CoA) with batch-specific data. Bulk buyers (10+ grams) may negotiate pricing, especially for GLP/GMP-grade material. Consider suppliers offering stable isotope-labeled versions (e.g., corticosterone-d8) for mass spectrometry applications. Lead times vary; specialized grades may require 2-4 weeks for synthesis and QC.
Related Manufacturers
- 主营：大鼠皮质酮、ELISA试剂盒、PCR试剂盒、科研试剂
- 主营：elisa 试剂盒、Elisa试剂盒、进口试剂盒、大鼠皮质酮、国产试剂盒、试剂、细胞、ELISA检测试剂盒、酶联免疫法、酶联免疫试剂盒、酶活性检测、酶标仪检测
- 主营：科研试剂盒、酶免试剂盒、elisa试剂盒、大鼠皮质酮、细胞、生物试剂、进口ELISA试剂盒、PCR试剂盒、生化测试盒
- 主营：ELISA试剂盒、抗体
- 主营：ELISA试剂盒、细胞培养系列、PCR相关、大鼠皮质酮、透析袋系列、实验耗材系列、实验室试剂系列
- 主营：大鼠皮质酮、Elisa试剂盒、检测试剂盒
- 主营：大鼠皮质酮、检测试剂盒、elisa试剂盒
- 主营：10ul吸头、巴氏吸管、离心管、大鼠皮质酮、透析袋、琼脂糖、国产试剂
- 主营：大鼠皮质酮、ELISA试剂盒、PCR试剂盒、科研试剂
- 主营：大鼠皮质酮、ATCC细胞系、原代细胞、原代永生化
- 主营：scl-70igg、人1α羟、试剂盒、大鼠11β、大鼠8羟基、大鼠25羟基、葡聚糖、16α羟基、1iga抗体、胶原c端、2-he2elisa、1igm抗体、25二羟基、17羟孕酮、dna糖苷酶、5α还原酶、研启生物、去氢血栓、人胰岛素、胶原n末端、25羟基维生、2，5寡腺苷、11脱氢血栓、羟基壬烯醛、三磷酸肌醇
- 主营：大鼠皮质酮、检测试剂盒
- 主营：ELISA检测试剂盒
- 主营：大鼠皮质酮、试剂盒
- 主营：大鼠皮质酮、试剂盒、信号调节激酶、人转谷氨酰胺酶